以電紡技術製備蠶絲/玻尿酸奈米纖維及其應用之研究

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以電紡技術製備蠶絲/玻尿酸奈米纖維及其應用之研究

Preparation of Silk Fibroin/Hyaluronic Acid Nanofibers Via Electrospinning Technique and Its Application

李慧君 , Masters　　Advisor：陳志勇　　

繁體中文

電紡絲技術；蠶絲蛋白；玻尿酸； MG-63 ； NIH/3T3 ； electrospinning technique ； silk fibroin ； hyaluronic acid ； MG-63 ； NIH/3T3

Abstract │ Reference (77) │ Altmetrics

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In the present study, we prepared silk fibroin and silk fibroin/hyaluronic acid nanofibers mats via electrospinning technique. Because of the natural silk fibroin protein and polysaccharide, they have the biocompatibility and biodegradable properties. Fibers with nanoscale diameter provide benefits due to high surface area. Therefore, these electrospun mats have been used in biomedical field in recent years.
In this study electrospun silk fibroin nanofibers mats with average diameter of 175.4±33.4 nm were measured by scanning electronic microscope (SEM). In addition this study also prepared three different concentrations of hyaluronic acid electrospun mats with average diameter of 179.8 ± 36.5, 139.9 ± 34, and 152.7 ± 29.3 nm, respectively. After methanol treatment, the electrospun mats could hardly dissolve in water, and FTIR showed that the conformation of the electrospun mats was mainly -sheet crystal. The thermal properties and mechanical properties could also be measured by Differential scanning calorimeter (DSC) and Nanoindenter.
Proliferation of MG-63 and NIH/3T3 on the electrospun mats was studied. From the experimental results we proved that the electrospun mats are non-cytotoxic. We also found that the amount of cell proliferation from the silk fibroin/hyaluronic acid nanofibers mats was higher than that of silk fibroin/hyaluronic acid nanofibers mats. With the increasing hyaluronic acid concentration, the amount of cell proliferation was also increased. We demonstrated that there is a positive response influence on the electrospun mats which the presence of hyaluronic acid.

Reference ( 77 ) 〈TOP〉

[11] Z. M. Huang, Y. Z. Zhang, M. Kotaki and S. Ramakrishna, Composites Science and Technology 2003, 63, 2223-2253.
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[12] N. Bhardwaj and S. C. Kundu, Biotechnology Advances 28, 325-347.
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[25] Q. P. Pham, U. Sharma and A. G. Mikos, Biomacromolecules 2006, 7, 2796-2805.
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[26] C. X. Zhang, X. Y. Yuan, L. L. Wu, Y. Han and J. Sheng, European Polymer Journal 2005, 41, 423-432.
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[27] I. Hayati, A. I. Bailey and T. F. Tadros, Journal of Colloid and Interface Science 1987, 117, 205-221.
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