功能性聚胜肽生物複合材料：合成、鑑定及自組裝行為

林詠智

3.238.70.175，Hello！

Close
Search Quick Search Advanced Search Publication Search	Personal Service Member Login Searching History Use Bonus Card SYMSKAN
Browse Browse by University of Graduate Thesis Browse by Pinyin of Graduate Thesis Browse by Conference Proceedings Topic Browse by Conference Proceedings Publisher Browse by Pinyin of Conference Proceedings Browse by eBook Category Browse by eBook Topic Browse by eBook Publisher
Customer Services Authorize Airiti Recommend a Journal

Search Symbol (Half-width)	Description of Search Symbols
Space	"AND" indicates the intertwining of key terms used in a search
Double Quotation Marks ("") ( " " )	Double quotation marks indicate the beginning and end of a phrase, and the search will only include terms that appear in the same order of those within the quotations. Example: "image process" ： " image process "
?	Indicates a variable letter. Entering two ? will indicate two variable letters, and so on. Example: "Appl?", search results will yield apple, apply… e , appl y … ( (often used to English word searches) )
*	Indicates an unlimited number of variable letters to follow, from 1~n. Example: Enter "appl*", search results will yield apple, apples, apply, applied, application…(often used in English word searches) e , appl es , appl y , appl ied , appl ication … ( (often used to English word searches) )
AND、OR、NOT	Boolean logic combinations of key words is a skill used to expand or refine search parameters. (1) AND (1) AND: Refines search parameters (2) OR (2) OR: Expands search parameters (3) NOT: Excludes irrelevant parameters

DOI stands for Digital Object Identifier （ D igital O bject I dentifier ） ,
and is the unique identifier for objects on the internet. It can be used to create persistent link and to cite articles.

Using DOI as a persistent link

To create a persistent link, add「http://dx.doi.org/」「 http://dx.doi.org/ 」 before a DOI.
For instance, if the DOI of an article is 10.5297/ser.1201.002 , you can link persistently to the article by entering the following link in your browser: http://dx.doi.org/ 10.5297/ser.1201.002 。
The DOI link will always direct you to the most updated article page no matter how the publisher changes the document's position, avoiding errors when engaging in important research.

Cite a document with DOI

When citing references, you should also cite the DOI if the article has one. If your citation guideline does not include DOIs, you may cite the DOI link.

DOIs allow accurate citations, improve academic contents connections, and allow users to gain better experience across different platforms. Currently, there are more than 70 million DOIs registered for academic contents. If you want to understand more about DOI, please visit airiti DOI Registration （ doi.airiti.com ）。

Data Source

College of Engineering > Department of Materials and Optoelectronic Science
Engineering > Electrical Engineering

Bibliography Management Tool

Related Links

Report an Issue

Search in Library

There is no full-text available at the moment. Airiti would like to request author's authorization. I would like to provide authorization.

功能性聚胜肽生物複合材料：合成、鑑定及自組裝行為

Functional Polypeptides-based Biohybrid: Synthesis, Characterization and Self-Assembly Behavior

林詠智 , Ph.D　　Advisor：郭紹偉　　

英文

二級結構；聚胜肽；環糊精；自組裝；多面體矽氧烷寡聚物；生醫複合材料；奈米碳管； Carbon nanotubes ； Secondary structure ； Self-assembly ； POSS ； Polypeptides ； Biohybrid materials ； Cyclodextrins

Abstract │ Reference (309) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Polypeptides have been widely studied due to the potential applications in various scientific fields and the close relationship to molecular recognition, proteins and drug delivery applications. In this study, we summarize variety in the preparation of functional peptide-containing biopolymer mixtures and the supramolecular structures they form via noncovalent bonding interactions. 
First of all, we used click chemistry to synthesize linear polypeptide-b-polyhedral oligomeric silsesquioxane (PBLG-b-POSS) copolymers. The incorporation of the POSS unit at the chain end of the PBLG moiety allowed intramolecular hydrogen bonding to occur between the POSS and PBLG units, thereby enhancing the α-helical conformation in the solid state, Thermogravimetric analysis indicated that the thermal degradation temperature increased significantly after incorporation of the POSS moiety. Next, we linked the POSS moiety on the side chain of the oligopeptides, the incorporation of the POSS unit at the side chain of the PPLG moiety enhanced the α-helical conformation in the solid state even those with relatively low DPs. PPLG-g-POSS underwent hierarchical self-assembly, to form a hexagonal cylinder packing nanostructure featuring α-helical conformations and POSS aggregates. Furthermore, we used a combination of atom transfer radical polymerization, ring opening polymerization, and click chemistry to synthesize new hierarchical organic/inorganic nanohybrid materials of PS-b-(PPLG-g-POSS). After attaching POSS nanoparticles to the side chains of PS-b-PPLG copolymers, the fraction of α-helical secondary structures increased and exhibited greater conformation stability and superior thermal properties, including Tg behavior, relative to those of the unmodified PS-b-PPLG copolymers. TEM analyses confirmed that the PS-(b-PPLG-g-POSS) copolymers underwent hierarchical self-assembly to form hexagonally packed cylindrical nanostructures. Moreover, we also prepared cyclodextrin-containing biopolymers (PPLG-g-CD), obtaining a self-assembling structure with a highly stable α-helical conformation and water-solubility. In addition, the presence of the CD cavities allowed the grafted polymers to form inclusion complexes with low-molecular-weight compounds, providing macromolecules with potential biomedical applications. Finally, we mixing the PPLG-g-Py oligomers with multiwalled carbon nanotubes (MWCNTs) in dimethylformamide led to the formation of highly dispersible PPLG-g-Py/MWCNT biohybrid materials. Fluorescence emission spectra revealed significant π–π stacking interactions between the PPLG-g-Py oligomers and the MWCNTs in these complexes.

Reference ( 309 ) 〈TOP〉

1-5 Reference
連結：
1. Meyer, D. E.; Chilkoti, A. Biomacromolecules, 2002, 3, 357.
連結：
2. Deming, T. J. Adv. Mater., 1997, 9, 299.
連結：
3. Klok, H. A.; Lecommandoux, S. Adv. Mater., 2001, 13, 1217.
連結：
4. Sela, M.; Katchalski, E. Adv. Protein Chem., 1959, 14, 391.
連結：

Altmetrics

〈TOP〉

E-mail ：

When an article is available to download, a notice will be sent to your mailbox address.

E-mail ：