泥漿進樣結合流動注入化學蒸氣生成技術感應耦合電漿質譜儀於乳液及唇膏樣品中鍺、砷、鎘、銻、汞、鉍及鉛之應用

陳韋霓

18.207.108.182，Hello！

Close
Search Quick Search Advanced Search Publication Search	Personal Service Member Login Searching History Use Bonus Card SYMSKAN
Browse Browse by University of Graduate Thesis Browse by Pinyin of Graduate Thesis Browse by Conference Proceedings Topic Browse by Conference Proceedings Publisher Browse by Pinyin of Conference Proceedings Browse by eBook Category Browse by eBook Topic Browse by eBook Publisher
Customer Services Authorize Airiti Recommend a Journal

Search Symbol (Half-width)	Description of Search Symbols
Space	"AND" indicates the intertwining of key terms used in a search
Double Quotation Marks ("") ( " " )	Double quotation marks indicate the beginning and end of a phrase, and the search will only include terms that appear in the same order of those within the quotations. Example: "image process" ： " image process "
?	Indicates a variable letter. Entering two ? will indicate two variable letters, and so on. Example: "Appl?", search results will yield apple, apply… e , appl y … ( (often used to English word searches) )
*	Indicates an unlimited number of variable letters to follow, from 1~n. Example: Enter "appl*", search results will yield apple, apples, apply, applied, application…(often used in English word searches) e , appl es , appl y , appl ied , appl ication … ( (often used to English word searches) )
AND、OR、NOT	Boolean logic combinations of key words is a skill used to expand or refine search parameters. (1) AND (1) AND: Refines search parameters (2) OR (2) OR: Expands search parameters (3) NOT: Excludes irrelevant parameters

DOI stands for Digital Object Identifier （ D igital O bject I dentifier ） ,
and is the unique identifier for objects on the internet. It can be used to create persistent link and to cite articles.

Using DOI as a persistent link

To create a persistent link, add「http://dx.doi.org/」「 http://dx.doi.org/ 」 before a DOI.
For instance, if the DOI of an article is 10.5297/ser.1201.002 , you can link persistently to the article by entering the following link in your browser: http://dx.doi.org/ 10.5297/ser.1201.002 。
The DOI link will always direct you to the most updated article page no matter how the publisher changes the document's position, avoiding errors when engaging in important research.

Cite a document with DOI

When citing references, you should also cite the DOI if the article has one. If your citation guideline does not include DOIs, you may cite the DOI link.

DOIs allow accurate citations, improve academic contents connections, and allow users to gain better experience across different platforms. Currently, there are more than 70 million DOIs registered for academic contents. If you want to understand more about DOI, please visit airiti DOI Registration （ doi.airiti.com ）。

Data Source

Basic & Applied Sciences > Chemistry
College of Science > Department of Chemistry

Bibliography Management Tool

Related Links

Report an Issue

Search in Library

There is no full-text available at the moment. Airiti would like to request author's authorization. I would like to provide authorization.

泥漿進樣結合流動注入化學蒸氣生成技術感應耦合電漿質譜儀於乳液及唇膏樣品中鍺、砷、鎘、銻、汞、鉍及鉛之應用

Determination of Ge、As、Cd、Sb、Hg、Bi and Pb in cosmetics using FIA-CVG-ICP-MS with slurry sample

陳韋霓 , Masters　　Advisor：江旭禎　　

繁體中文

唇膏；化學蒸氣生成法；同位素稀釋法；感應耦合電漿質譜儀；乳液； Isotope dilution ； ICP-MS ； CVG ； Lipsticks ； Creams

Abstract │ Reference (92) │ Altmetrics

Abstract 〈TOP〉

化學蒸氣生成法最早在1973年由Braman等人所發展出的樣品輸入技術，其利用分析物於酸性環境下與NaBH4試劑反應形成氫化物，氫化物之熔點與沸點相較於原分析物下降許多，因此產物會以氣態的形式存在於混合液中，再藉由氣液分離裝置將氫化物從液體分離並送入偵測器。由於氫化物為氣態，相對於傳統氣動式霧化器可得到較高之樣品傳輸效率（Sample transport efficiency），因此可提升靈敏度、降低偵測極限，另外氣液分離裝置（Gas-liquid separator，GLS）能將分析物與基質分離，而降低光譜及非光譜性干擾。
    相較於其他文獻報導化粧品樣品需要經強酸或強鹼消化再進行分析，本研究利用泥漿進樣配合流動注入與氣液分離裝置注入樣品，可以簡化樣品前處理的繁雜程序，避免樣品前處理過程中導入汙染物及降低樣品損失等優點。
    研究分為兩部份，第一部份利用泥漿進樣結合流動注入化學蒸氣生成技術感應耦合電漿質譜儀分析乳液中鍺、砷、鎘、銻、汞及鉍的含量。研究中添加界面活性劑Triton X-100製備乳液泥漿溶液，並以此作為樣品基質探討蒸氣生成變數，包含NaBH4濃度、樣品及載體溶液中Thiourea、L-cysteine及Co(II)的濃度，尋求蒸氣生成及感應耦合電漿質譜儀最適化操作條件。將分析條件最適化後，在乳液基質中添加適量的元素標準溶液，分析物訊號波峰面積及高度相對標準偏差（RSD）均在5%以內（n = 5）。實驗中比較水溶液校正法（External calibration）及標準添加法（Standard addition）之斜率，證明基質會影響蒸氣生成表現，故選擇以標準添加法及同位素稀釋法進行定量，以標準添加法估計得到鍺、砷、鎘、銻、汞及鉍之方法偵測極限可小至0.02、0.03、0.20、0.02、0.35、0.03 ng g-1。元素之物種形態會影響化學蒸氣生成效果，可能導致定量上的偏差，因此比較As(III)、As(V)及Sb(III)、Sb(V)在經過泥漿製備法後化學蒸氣生成效率，結果證實泥漿樣品之預還原效果已達完全。最後以探討完之最適化條件分析標準參考樣品GBW09305（Cream）霜類化粧品及三種不同品牌之市售乳液來證實方法準確性及適用性。
    第二部分研究利用泥漿進樣結合流動注入化學蒸氣生成技術感應耦合電漿質譜儀分析唇膏中鉛的含量。相較於傳統應用於化學蒸氣生成之元素，鉛之氫化物（PbH4，Plumbane）生成不易，需要合適的氧化劑及螯合劑搭配才能有效的形成。Pb(IV)之氫化物生成效率較Pb(II)高，樣品中之Pb(II)需被轉化為Pb(IV)才能有效形成氫化物。文獻指出亞鐵氰化鉀（K3Fe(CN)6）藉由與NaBH4作用形成較具反應性的中間產物（hydroborane），進而促進PbH4之生成效率。實驗中將以泥漿方式進樣並尋求系統最適化，包含酸及增益試劑選擇、K3Fe(CN)6濃度、HNO3濃度、NaBH4濃度及反應試劑流速等。探討完最適化條件，以標準添加法估計所得鉛偵測極限可小至0.11 ng g-1。鉛之訊號再現性以相對標準偏差（RSD）表示皆小於3%，顯示本研究方法具有高重複性；而同位素比的RSD均在1.2%以內，證實同位素比的測量有很好的訊號重複性，因此同位素稀釋法是很理想的定量方式。最後，以所開發之分析方法偵測標準參考樣品GBW09305及七種不同種類之市售唇膏中鉛含量來驗證方法準確性及適用性。

關鍵詞:化學蒸氣生成法、感應耦合電漿質譜儀、同位素稀釋法、乳液、唇膏

Parallel Abstract 〈TOP〉

Abstract
Chemical vapor generation（CVG）is a powerful sample introduction technique, which is used for inductively coupled plasma mass spectrometry（ICP-MS）to improve sensitivity and to eliminate matrix effect. Analytes can be transformed to hydride or elemental vapor through chemical reaction. The gaseous analytes have higher transport efficiency than pneumatic nebulizer, therefore it has the better sensitivity and lower detection limit. CVG system can separate analytes from matrix by a gas-liquid separator, so it can avoid spectral and non-spectral interferences caused by matrix elements.
First research is using slurry sampling as pretreatment, and to determine Ge, As, Cd, Sb, Hg and Bi in creams by FIA-CVG-ICP-MS. The cream slurry containing 2% m/v cream, 2% m/v Thiourea, 0.05% m/v L-cysteine, 0.5 μg L-1 Co(II) and 1.2% v/v HCl. The quantifications have been carried out using standard addition and isotope dilution methods. The influences of vapor generation conditions on the analyte signals were reported. This method has been applied for the determination of Ge, As, Cd, Sb, Hg and Bi in cream samples obtained from the local markets. The analytical results of cream cosmetics certified reference material（GBW09305）determined by standard addition and isotope dilution methods were in a good agreement with ETV-ICP-MS and those of digested samples analysed by pneumatic nebulization ICP-MS. Under the optimum operating conditions, the detection limit obtained from the standard addition curve was in the range of 0.02-0.45 ng g-1 for Ge, As, Cd, Sb, Hg and Bi, respectively, in the cream samples.
Second research is using slurry sampling as pretreatment, and to determine Pb in lipsticks by FIA-CVG-ICP-MS. The lipstick slurry containing 1% m/v cream, 0.5 m/v K3Fe(CN)6 and 0.5% v/v HNO3. The quantifications have been carried out using standard addition and isotope dilution methods. The influences of vapor generation conditions on the Pb signal were reported. This method has been applied for the determination of Pb in lipstick samples obtained from the local markets. The analytical results of cream cosmetics certified reference material（GBW09305）determined by standard addition and isotope dilution methods were in a good agreement with those of digested samples analysed by pneumatic nebulization ICP-MS. The method provided good reproducibility and the best detection limit was found to be 0.11 ng g-1 in the cream sample.
Key word: CVG, ICP-MS, Isotope dilution, Creams, Lipsticks

Reference ( 92 ) 〈TOP〉

1. Ying, G.; Rui, L.; Lu, Y., Application of chemical vapor generation in ICP-MS. Chin. Sci. Bull., 2013, 58, 1980-1991
連結：
2. Yan, X. P.; Ni, Z. M., Vapor generation atomic absorption spectrometry. Anal. Chim. Acta., 1994, 291, 89-105
連結：
3. Chen, Z. C.; Jiang, S. J., Determination of Ge, As and Se in nickel-based alloys by flow injection hydride generation dynamic reaction cell inductively coupled plasma mass spectrometry. J. Anal. At. Spectrom., 2006, 21, 566-573
連結：
4. Wu, P.; He, L. A.; Zheng, C. B. et al., Applications of chemical vapor generation in non-tetrahydroborate media to analytical atomic spectrometry. J. Anal. At. Spectrom., 2010, 25, 1217-1246
連結：
5. Madrid, Y.; Camara, C., Lead hydride generation atomic absorption spectrometry: an alternative to electrothermal atomic absorption spectrometry. Analyst, 1994, 119, 1647-1658
連結：

Altmetrics

〈TOP〉

E-mail ：

When an article is available to download, a notice will be sent to your mailbox address.

E-mail ：