利用近紅外線光譜儀系統進行腦灌注壓評估

賴建甫

doi:10.6842/NCTU.2013.00424

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利用近紅外線光譜儀系統進行腦灌注壓評估

Level estimation of cerebral perfusion pressure by using near infrared spectroscopy

賴建甫 , Masters　　Advisor：林伯昰　　

英文 DOI： 10.6842/NCTU.2013.00424

腦創傷；近紅外線光譜儀；含氧血紅素；非含氧血紅素；全血紅素；腦灌注壓； Traumatic brain injury ； near-infrared spectroscopy ； oxy-hemoglobin ； deoxy-hemoglobin ； total-hemoglobin ； cerebral perfusion pressure

Abstract │ Reference (38) │ Altmetrics

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Prevention of secondary brain injury after Traumatic brain injury (TBI) is important in clinical. Cerebral perfusion pressure is associated with blood flow into the brain, and indirectly reflects the cerebral ischemia and oxygenation. Recently, near infrared spectroscopy (NIRS) have been developed and is available to access the cerebral ischemia and hypoxia non-invasively. In this study, we used proposed wireless NIRS system, and commercial intracranial pressure (ICP) and mean arterial pressure (MAP) devices to monitor rat’s brain in different impact strengths of trauma. With the increased impact strength, the relationship between CPP and NIRS parameters will be investigated. Results show that the ∆CPP and NIRS parameters were inversely proportional to the increased impact strengths, and the correlation coefficient between ∆CPP, and ∆[HbO2], ∆[HbT], and ∆[HbR] are 0.73, 0.6, and 0.36 respectively. Therefore, NIRS system is useful to assess the level of cerebral perfusion pressure non-invasively.

Reference ( 38 ) 〈TOP〉

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連結：
[11] S. Gopinath, C. Robertson, C. Contant, C. Hayes, Z. Feldman, R. Narayan, and R. Grossman, "Jugular venous desaturation and outcome after head injury," Journal of Neurology, Neurosurgery & Psychiatry, vol. 57, pp. 717-723, 1994.
連結：
[12] G. S. U. Rao and P. Durga, "Changing trends in monitoring brain ischemia: from intracranial pressure to cerebral oximetry," Current Opinion in Anesthesiology, vol. 24, pp. 487-494, 2011.
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