- 期刊
Feline Lymphoplasmacytic Stomatitis: Report of Six Cases
貓淋巴細胞－漿細胞性口炎：六個病例報告
摘要
自1998年七月至2000五月，有六隻貓，五公一母，年齡由三歲至九歲經台灣大學農學院附設動物醫院診斷為貓淋巴細胞－漿細胞性口炎。病貓的臨床特徵包括食慾不振及流涎，口腔內齒齦、頰部、舌顎弓、及舌表面有腫瘤樣團塊或苔蘚樣紅色凸起生長物，經生檢採樣進行病理學檢查。在光學顯微鏡下，黏膜增生或潰瘍，黏膜下層組織出現大量成熟漿細胞、淋巴球及Russell's bodies，此外，水腫及血管增生情形亦可見。在表面潰瘍病例，多量嗜中性球夾雜於漿細胞、淋巴球及黏膜層。其中一隻以ELISA方法檢測貓白血病病毒(FeLV)抗原及貓免疫不全病毒(FIV)抗體，均呈陰性反應。三隻病貓對類固醇藥物治療，可暫時緩解疾病，但是停藥後，又再復發。本病在台灣地區未有正式文獻報告，而且易與腫瘤及其它慢性口腔內炎症混淆，報告這些病例，希望有助於獸醫師對本病的了解，以便早期診斷並給予適當治療。
並列摘要
Six cats, five male and one female , aging from 3 years to 9 years old were diagnosed with feline lymphoplasmacytic stomatitis at our university veterinary hospital from July 1998 to May 2000. The major clinical signs of the sick cats were anorexia, difficulty in prehension of foods, pain, and ptyalism. Physical examination showed erythromatous, raised, ulcerative, and proliferative lesions on the gingiva, buccal mucosa, glossopalatine arches, and tongue. Microscopic examination revealed a marked and extensive infiltrate of admixtures of mature plasma cells and lymphocytes associated with mucosal hyperplasia. The mature plasma cells with Russell's bodies, forming intracytoplasmic globules and bulging from the cytoplasm, were frequently seen. Moderate edema and newly formed blood vessels were observed. In ulcerative areas, a number of neutrophils are accompanying with lymphoplasmacytic infiltrate. ELISA for Feline leukemia virus (FeLV) antigen and feline immunodificiency virus (FIV) antibody was tested in one cat but with negative result. Three affected cats had been received corticosteroid treatment. Symptoms were temporarily relieved, but recurred once treatment had ended. The definite diagnosis is made on the basis of clinical signs and characteristic histopathological findings. To our knowledge, the disease has not been reported in Taiwan, increased awareness of this disease will allow the veterinarians for making earlier diagnosis and more effective treatment.