衛生署於78年2月頒發公告,增列Cimetidine為必需實施溶離度試驗藥物之一,本組於78年11月下旬起分批赴北、中、南各縣市抽購市售Cimetidine製劑30件,依美國藥典第廿二版所載方法,進行檢驗。結果30件錠劑檢體中,不符合美國藥典規定者5件,其不合格率達16.7%。
Thirty samples of commercial Cimetidine tablets were purchased between November 1989 and January 1990 around Taiwan area. All samples were evaluate- don weight variation and Dissolution according to USP XXII. Only one sample didn't meet Weight Variation Test, 5 samples failed to meet USP requirement for Dissolution test.