Hormone Replacement Therapy and Menopause: A Review of Randomized, Double-blind, Placebo-controlled Trials

荷爾蒙療法常用來治療健康女之更年期症狀，及長期使用(≧1年)於預防老年婦女慢性病。本文藉由回顧國際醫學學術資料庫(MEDLNE)關於更年期婦女荷爾蒙使用之利弊，及所發表台灣更年期或荷爾蒙療法之研究，以俾提出台灣未來研究之建議。由於「隨機控制雙盲安慰劑實驗研究」為獲取可靠科學證據的最高標準，本文搜尋MEDLNE中自1966年1月至2002年7月間有關隨機控制雙盲實驗研究於更年期婦女之荷爾蒙療法，共23篇文獻(≧1年)符合搜尋標準，但並無發現長期追蹤研究於台灣，本搜尋結果顯示，婦女使用各種不同荷爾蒙製劑1年以上時，危險性是高於對健康婦女之助益；以及對有心臟疾病、老人失智症、子宮切除、子宮－輸卵管－卵巢切除、或有過中風之婦女並無幫助。如使用相同的MEDLNE搜尋於台灣之荷爾蒙療法或更年期有關研究，16篇文獻符合搜尋標準，但只有為短期荷爾蒙療法研究；而當中並未有任何研究證明長期荷爾蒙法對於更年期婦女是有益的。

關鍵字

荷爾蒙療法；更年期婦女；隨機雙盲；安慰劑

並列摘要

Hormone replacement therapy (HRT) is frequently prescribed to healthy women to ameliorate menopausal symptoms. HRT is used long term (≧1 year) to prevent chronic disease in older women. The objective of this study was to review the benefits and risks of HRT and studies of menopause or HRT in Taiwan via a MEDLINE search. Recommendations are provided for future HRT research in Taiwan. Randomized, double-blind, placebo-controlled clinical trials are considered the gold standard of scientific evidence. A MEDLINE literature search (January 1966-July 2002) identified 23 papers on trials (≧1 year) that met the inclusion criteria. The results showed that various HRT regimens used for more than 1 year caused more harm than good in healthy menopausal women and that there was no benefit for women with coronary artery disease, Alzheimer’s disease, hysterectomy, hysterosalpingo-oophorectomy, and ischemic stroke. None of this research was conducted in Taiwan. A MEDLINE search using the key words “estrogen replacement therapy and menopause in Taiwan” identified 16 studies. There was only one, short-term, HRT trial. No evidence suggested benefits from long-term HRT in menopausal women in Taiwan.

並列關鍵字

hormone therapy ； menopausal women ； randomized ； double-blind ； placebo

國際替代計量

Hormone Replacement Therapy and Menopause: A Review of Randomized, Double-blind, Placebo-controlled Trials

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