Expression of p53, DCC, and HER-2/Neu in Mucinous Carcinoma of the Breast

我們觀察11個單純黏液性乳癌及79個非黏液性侵襲性乳腺管乳癌比較病人年齡、腫瘤大小、腋下淋巴狀態，動情激素受體、黃體激素受體、HER-/neu及p53之表達。黏液比乳癌合併腋下淋巴腺轉移比非黏液性乳癌低（0%比63.1%；p=0.00l8），另外，黏液性乳癌比非黏液性乳癌更多DCC表達（100%比48.7%；p=0.0027)，更多動情激素受體表達（90.9%比26.9%；p=0.0023）但較少HER-2/neu表達（0%比38.1%；p=0.030）我們證實黏液性乳癌在臨床病理及腫瘤蛋白的表現上與非黏液性乳癌不同，因此合理解釋為黏液性乳癌有不同的生物特性及表現。

關鍵字

乳癌； DCC ； p53 ； HER-2/neu ；黏液性乳癌

並列摘要

We investigated the clinicopathologic and oncoprotein expression characteristics of 11 pure mucinous and 76 non-mucinous infiltrating ductal carcinomas in the human female breast. We compared patient age, tumor size, axillary lymph node status, and the expression of estrogen receptor (ER), progesterone receptor (PR), deleted-in-colon cancer (DCC), HER-2/neu, and p53. Mucinous carcinoma with axillary lymph node metastasis occurs less frequently than non-mucinous carcinoma (0% vs 63.1%; p=0.0018). Compared with the non-mucinous type, mucinous carcinoma specimens have more DCC expression (100% vs 48.7%; p=0.0027) and more ER expression (90.9% vs 26.9%; p=0.0023), but less HER-2/neu overexpression (0% vs 38.l%; p=0.0302). We confirmed that mucinous carcinoma samples from the breast reveal distinct clinicopathologic and oncoprotein expression features compared with non-mucinous carcinoma and, therefore, it seems reasonable to suggest different biologic characteristics and manifestations.

並列關鍵字

breast cancer ； DCC ； p53 ； HER-2/neu ； mucinous carcinoma

國際替代計量

Expression of p53, DCC, and HER-2/Neu in Mucinous Carcinoma of the Breast

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