Effects of Laser in Situ Keratomileusis on the Corneal Endothelium

評估雷射角膜內層重塑術(LASIK)術後對角膜內皮細胞之影響。前瞻性研究角膜內皮細胞在LASIK術前和術後一個月的狀況。病人分為術前使用隱形眼鏡和從未使用過隱形眼鏡兩組。角膜內皮細胞分析指標為細胞密度，六角形細胞比例及細胞大小變異係數。在87隻眼睛中，平均細胞密度及六角形細胞比例在LASIK術後一個月明顯上升。平均細胞大小變異係數則無顯著差異。在術前使用隱形眼鏡的病人中（48隻眼睛）平均細胞密度及六角形細胞比例在LASIK術後一個月明顯增加，但平均細胞大小變異係數則無顯著差異。在從未使用過隱形眼鏡的病人中（39隻眼睛）細胞密度，六角形細胞比例平均及細胞大小變異係數皆沒有顯著差異。LASIK並不會造成角膜內皮細胞的傷害。術前使用隱形眼鏡的病人，在平均細胞密度及六角形細胞比例上的改善可能與術後不再配戴隱形眼鏡有關。

關鍵字

雷射角膜內層重塑術；角膜內皮細胞；隱形眼鏡

並列摘要

The purpose of this study was to assess the effects of laser in situ keratomileusis (LASIK) on the corneal endothelium. In a prospective study, the corneal endothelium of 87 eyes (45 patients) was examined before and 1 month after LASIK. Patients were divided into two groups: people who wear contact lenses (48 eyes) and people who had never worn contact lenses (39 eyes). The corneal endothelium was analyzed for cell density, percentage of hexagonal cells, and coefficient of variation (CV) of cell size. The mean cell density and percentage of hexagonal cells was significantly higher 1 month after LASIK for all 87 eyes. However, the mean CV of cell size was not significantly different. In contact lens wearers, there was a significant increase in mean cell density and percentage of hexagonal cells, but there was no significant change in mean CV of cell size after LASIK. Among patients who had never worn contact lenses, no significant changes were noted in mean cell density, percentage of hexagonal cells, or mean CV of cell size. In this study, LASIK caused no damage to the corneal endothelium. Postoperative improvements in the mean cell density and percentage of hexagonal cells in patients who were contact lens wearers may be related to the discontinuance of contact lens use after LASIK.

並列關鍵字

LASIK ； corneal endothelium ； contact lens

國際替代計量

Effects of Laser in Situ Keratomileusis on the Corneal Endothelium

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