Determination of the Minimum Effective Dosages of Praziquantel, Albendazole, and Mebendazole against Clonorchis Sinensis Infection in Rats

測定吡喹酮、阿苯達唑及甲苯達唑治療大白鼠中華肝吸蟲感染最低有效劑量

范秉真(Ping-Chin Fan) ； 吳金正(Chin-Cheng Wu) ； 黃萍(Ping Huang) ； 顏至蔚(Chih-Wei Yen)

《The Kaohsiung Journal of Medical Sciences》 21卷10期 (2005/10) Pp. 448-451

摘要

應用不同劑量吡哇酮、阿苯達唑及甲苯達唑測定治療SD大白鼠感染中華肝吸蟲病之最低有效劑量。每一SD大白鼠實驗感染30個囊狀幼蟲。感染後25天用吡喹酮治療或感染後11天用阿苯達唑及甲苯達唑治療，而後犧牲大鼠檢查蟲量。吡唑酮、阿苯達唑及甲苯達唑治療測定之最低有效劑量分別為每公斤375毫克、150毫克及150毫克。上述劑量是否可用於治療人體感染中華肝吸蟲病尚待確定。

關鍵字

阿苯達唑 ； 中華肝吸蟲 ； 甲苯達唑 ； 最低有效劑量 ； 吡喹酮

並列摘要

In order to determine the minimum effective dosages of praziquantel, albendazole, and mebendazole against Clonorchis sinensis infection in Sprague-Dawley rats, each rat was infected with 30 metacercariae and treated with one of three drugs. The rats were killed and examined 25 days after praziquantel treatment or 11 days after albendazole or mebendazole treatment. The minimum effective dosages were a single dose of praziquantel 375 mg/kg, albendazole 150 mg/kg, and mebendazole 150 mg/kg. Trials are required to determine whether these dosages are useful in the treatment of human clonorchiasis.

並列關鍵字

albendazole ； Clonorchis sinensis ； mebendazole ； minimum effective dosage ； praziquantel