- 期刊
Effects of Cervical-Lymphatic Blockade on Brain Edema and Infarction Volume in Cerebral Ischemic Rats
並列摘要
To observe the effects of cervical-lymphatic blockade (CLB) on brain edema and infarction volume of ischemic (MCAO) rat, we examined changes in cerebral water content, Ca(superscript 2+) and glutamate concentrations, cerebral infarction volume and mRNA expression levels of N-methyl-D-aspartame receptor 1 (NMDA receptor 1) in the ischemic (left) hemisphere. The present results demonstrated that all the above indices in rats with middle cerebral artery occlusion plus cervical lymphatic blockade (MCAO+CLB) were markedly higher than those with only middle cerebral artery occlusion (MCAO) at different time points. These results indicate that CLB can aggravate cerebral ischemia by increasing brain edema and infarction volume.
參考文獻
Beck, J.,Lenart, B.,Kintner, D.B.,Sun, D.(2003).Na-K-Cl cotransporter contributes to glutamate-mediated excitotoxicity.J. Neurosci.23,5061-5068.
Bederson, J.B.,Pitts, L.H.,Nishimura, M.C.,Davis, R.L.,Bartkowski, H.M.(1986).Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.Stroke.17,1304-1308.
Bradbury, M.W.,Gserr, H.F.,Westrop, R.J.(1981).Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit.Am. J. Physiol..240,329-336.
Brailoiu, E.,Brailoiu, G.C.,Mameli, G.,Dolei, A.,Sawaya, B.E.,Dun, N.J.(2006).Acute exposure to ethanol potentiates human immunodeficiency virus type 1 Tat-induced Ca(superscript 2+) overload and neuronal death in cultured rat cortical neurons.J. Neurovir..12,17-24.
Caccamo, D.,Campisi, A.,Curro, M.,Li Volti, G.,Vanella, A.,Ientile, R.(2004).Excitotoxic and post-ischemic neurodegeneration: Involvement of transglutaminases.Amino Acids.27,373-379.
延伸閱讀
- Lin, M. C. (2008). Study on the Dynamic Changes of Extracellular Trace Elements and Energy Metabolites in Brain Cortex of Gerbil during Cerebral Ischemia and Reperfusion [doctoral dissertation, Kaohsiung Medical University]. Airiti Library. https://doi.org/10.6832/KMU.2008.00106
- Lou, H. Y., Zhang, X. M., Wei, X. B., Wang, R. X., & Sun, X. (2004). Anti-inflammatory Effect of Hydroxyethylpuerarin on Focal Brain Ischemia/Reperfusion Injury in Rats. The Chinese Journal of Physiology, 47(4), 197-201. https://www.airitilibrary.com/Article/Detail?DocID=03044920-200412-47-4-197-201-a
- Yang, C. S., Tsai, P. J., Lin, N. N., & Kuo, J. S. (2000). Diethylmaleate Decreased Ascorbic Acid Release Induced by Cerebral Ischemia in Cerebral Cortex of the Anesthetized Rat. The Chinese Journal of Physiology, 43(2), 49-53. https://www.airitilibrary.com/Article/Detail?DocID=03044920-200006-43-2-49-53-a
- Kiray, M., Bagriyanik, H. A., Pekcetin, C., Ergur, B. U., & Uysal, N. (2008). Protective Effects of Deprenyl in Transient Cerebral Ischemia in Rats. The Chinese Journal of Physiology, 51(5), 275-281. https://www.airitilibrary.com/Article/Detail?DocID=03044920-200810-51-5-275-281-a
- Zheng, Y. H., Xia, Z. L., Chen, L. B., Zhao, X. M., Xia, Q., & Song, X. J. (2008). Variations in Blood Pressure and Heart Rate in Conscious Rats with Cervical Lymphatic Blockade. The Chinese Journal of Physiology, 51(3), 178-185. https://www.airitilibrary.com/Article/Detail?DocID=03044920-200806-51-3-178-185-a