- 期刊
Effects of Ulinastatin, a Urinary Trypsin Inhibitor, on Synaptic Plasticity and Spatial Memory in a Rat Model of Cerebral Ischemia/Reperfusion Injury
並列摘要
Established therapies for cerebral ischemia-reperfusion injury are currently limited. The urinary trypsin inhibitor ulinastatin (UTI) is considered cytoprotective against ischemia-reperfusion injury in internal organs through its anti-inflammatory activity. We aimed to investigate the neuroprotective effects of UTI on learning and memory of rats after cerebral ischemia-reperfusion injury. Rats were treated with UTI at 10,000 U/kg body weight, then underwent ischemia and reperfusion by the middle cerebral arterial occlusion (MCAO) method. At various times after the onset of reperfusion, we evaluated neurologic impairment scores. Brain sections underwent immunohistochemical staining for synaptophysin and calcium-binding protein S100β. Other rats underwent the Morris water maze test to determine the effects of UTI on learning and memory. Spatial reference learning and memory were improved with UTI treatment by down-regulating S100β-positive cells and preventing the loss of neural cells. Thus, UTI has a neuroprotective role on synaptic plasticity and spatial memory with cerebral ischemia-reperfusion injury in rats.
參考文獻
延伸閱讀
- Alvarez, V. M. B., Rodriguez, G. S., Barrios, J. A. G., Fong, D. M., Brambila, E., Soto, M. T., Peralta, A. K. A., Vazquez, A. G., Sanchez, C. T., Limón, I. D., Eguibar, J. R., Ugarte, A., Castillo, J. H., & Chavez, B. A. L. (2015). Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia. Neural Plasticity, 2015(), 514-528-043. https://doi.org/10.1155/2015/375391
- Merino, O. L., Landa, J. F. R., Caba, M., Juárez, M. C., Orduña, F. G., Vélez, M. S., Olguín, A. P., & Hernández, M. D. J. R. (2020). Acute effect of an infusion of Montanoa tomentosa on despair-like behavior and activation of oxytocin hypothalamic cells in Wistar rats. Journal of Traditional and Complementary Medicine, 10(1), 45-51. https://doi.org/10.1016/j.jtcme.2019.01.005
- Si, J. C., Chen, L. B., & Xia, Z. L. (2006). Effects of Cervical-Lymphatic Blockade on Brain Edema and Infarction Volume in Cerebral Ischemic Rats. The Chinese Journal of Physiology, 49(5), 258-265. https://www.airitilibrary.com/Article/Detail?DocID=03044920-200610-49-5-258-265-a
- Miao, Y. F., Wu, H., Yang, S. F., Dai, J., Qiu, Y. M., Tao, Z. Y., & Zhang, X. H. (2015). 5\'-Adenosine Monophosphate-Induced Hypothermia Attenuates Brain Ischemia/Reperfusion Injury in a Rat Model by Inhibiting the Inflammatory Response. Mediators of Inflammation, 2015(), 704-713-261. https://doi.org/10.1155/2015/520745
- Hsieh, C. C., Hsieh, S. C., Chiu, J. H., & Wu, Y. L. (2014). Protective Effects of N-acetylcysteine and a Prostaglandin E1 Analog, Alprostadil, Against Hepatic Ischemia: Reperfusion Injury in Rats. Journal of Traditional and Complementary Medicine, 4(1), 64-71. https://doi.org/10.4103/2225-4110.124351