- 期刊
Alteration of Cardiac ACE2/Mas Expression and Cardiac Remodelling in Rats with Aortic Constriction
並列摘要
The recent discovery of the new components of the renin-angiotensin system (RAS) suggests the importance of the maintenance of cardiovascular structure and functions. To assess the role of the angiotensin-converting enzyme 2 (ACE2)-Mas receptor axis in the regulation of cardiac structure and function, the present work investigated the expression of ACE2 and Mas receptor in the heart in the cardiac remodeling that occurs in aortic constricted rats. Partial abdominal aortic ligation was carried out in Sprague-Dawley rats. Angiotensin AT1 receptor blockade and ACE inhibition were achieved by losartan and enalapril treatment, respectively. Results showed that aortic constriction increased left ventricular hypertrophy, fibrosis, mean arterial pressure (MAP), plasma renin activity (PRA) and cardiac ACE levels, but decreased the expression of cardiac ACE2 and Mas receptor. Losartan treatment significantly decreased MAP, left ventricle hypertrophy (LVH), fibrosis, and increased cardiac ACE2 and Mas expression. Enalapril also improved the cardiac parameters with a rise in cardiac ACE2, but did not change the Mas level. In conclusion, aortic constriction results in cardiac hypertrophy, fibrosis and a rise of cardiac ACE expression. Both AT1 receptor blocker and ACE inhibitor play a cardioprotective role in aortic constriction. However, AT1 receptor blocker particularly promotes cardiac ACE2 and Mas receptor levels. ACE inhibitor is associated with the inhibition of ACE and normalization of cardiac ACE2 activity.
參考文獻
延伸閱讀
- Wong, K. K., Lo, C. F., & Chen, C. M. (1997). Endothelium-Dependent Higenamine-Induced Aortic Relaxation in Isolated Rat Aorta. 藥物食品檢驗局調查研究年報, (), 236-238. https://doi.org/10.6946/ASRNL.199709.0236
- Lo, Y. L. (2005). Comparison of cardiac control mechanism of nucleus ambiguus of the medulla in hypertensive and normotensive rats [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2005.02145
- Wu, C. E. (2017). Cardiac Pro-arrhythmic Risks and Autonomic Nerve Dysfunction in Collagen-induced Arthritis Rats [master's thesis, National Chiao Tung University]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0030-0705201811524809
- Chai, C. Y., & Chen, H. I. (1975). Cardiac Responses upon Intense Cerebral Compression in Rats. Journal of Medical Sciences, 1(1), 1-10. https://www.airitilibrary.com/Article/Detail?DocID=10114564-197501-201307100008-201307100008-1-10
- Huang, C. Y., Ueng, K. C., Wu, D. J., Hsu, H. H., Liu, J. Y., Kuo, W. W., Huang, C. M., Chu, C. H., Liu, C. J., & Chang, M. H. (2003). Captopril Inhibition of Cardiac Hypertrophy Induced by Coarctation of the Abdominal Aorta in Rats. 中山醫學雜誌, 14(2), 201-213. https://www.airitilibrary.com/Article/Detail?DocID=16803108-200305-14-2-201-213-a