Attenuated Effects of Deep-Sea Water on Hepatic Apoptosis in STZ-Induced Diabetic Rats

Tsai-Ching Hsu ； Chun-Ching Chiu ； Hsou-Lin Lin ； Tseng-Wei Kao ； Li-Jeng Chen ； Li-Yi Wu ； Chih-Yang Huang ； Bor-Show Tzang

《The Chinese Journal of Physiology》 58卷3期 (2015/06) Pp. 197-205

https://doi.org/10.4077/CJP.2015.BAD308

並列摘要

Diabetes mellitus (DM) is a metabolic disorder and increasing evidences have indicated a connection between DM and hepatic abnormality. Deep-sea water (DSW) has been applied in many fields, especially in medicine; herein, we investigated the influence of DSW on hepatic apoptosis in streptozocin (STZ)-induced diabetes rats. Our experimental results firstly demonstrated the beneficial effects of 1×DSW, 2×DSW and 3×DSW in alleviating hepatic apoptosis in STZ-induced diabetic rats. We demonstrated that 1×DSW, 2×DSW and 3×DSW significantly suppressed the caspase-3 activity and TUNEL-positive cells in livers of STZ-induced diabetic rats. Significant reductions of both Fas-dependent and mitochondrial-dependent apoptotic molecules were also detected in livers of STZ-induced diabetic rats receiving DSW. Additionally, apoptotic signaling molecules such as phosphorylated IκB-α and NF-κB were significantly reduced in livers of DSW-treated STZ-induced diabetic rats. These findings indicate hepatic protective effects of DSW on DM and suggest DSW as a possible ingredient for health food.

並列關鍵字

apoptosis ； deep-sea-water (DSW) ； diabetes mellitus (DM) ； liver ； magnesium (Mg) ； signaling

參考文獻

Chen, W.K.,Yeh, Y.L.,Lin, Y.M.,Lin, J.Y.,Tzang, B.S.,Lin, J.A.,Yang, A.L.,Wu, F.L.,Tsai, F.J.,Cheng, S,M.,Huang, C.Y.,Lee, S.D.(2014).Cardiac hypertrophy-related pathways in obesity.Chinese J. Physiol..57,111-120.

Lin, T.H.,Chen, W.C.,Wu, H.C.,Chien, W.S.,Lee, S.S.,Tsai, F.J.,Tsai, C.H.,Ting, W.J.,Kuo, S.C.,Huang, C.Y.(2014).Induction of apoptosis in human DU145 prostate cancer cells by KHC-4 treatment.Chinese J. Physiol..57,99-104.

Lin, J.F.,Lin, Y.H.,Liao, P.C.,Lin, Y.C.,Tsai, T.F.,Chou, K.Y.,Chen, H.E.,Tsai, S.C.,Hwang, T.I.(2014).Induction of testicular damage by daily methamphetamine administration in rats.Chinese J. Physiol..57,19-30.

Liu, H.,Sun, H.,Liu, C.(2011).Interference of the apoptotic signaling pathway in RGC stress response by SP600125 in moderate ocular hypertensive rats.Chinese J. Physiol..54,124-132.

Ahsan, S.K.(1997).Metabolism of magnesium in health and disease.J. Indian Med. Assoc..95,507-510.