- 期刊
Increased Serum High-Density Lipoprotein Cholesterol Level is Associated with a Reduction in Peripheral Monocyte Count in Normal Individuals
並列摘要
Background and Purpose: Monocytes and high-density lipoprotein cholesterol (HDL-C) both play important roles in the process of atherosclerosis. This retrospective study investigated whether an increase in serum HDL-C level would be followed by a reduction in monocyte count. Methods: A total of 781 participants in a health check program in 1996 who had received a second health check in 1997, 1998, or 1999 were included. Based on the change in HDL-C at the second health check, the subjects were divided into the following 3 groups: 1) increase in HDL-C of ≥5% (n=426); 2) change of HDL-C of ＜ 5% (n=162); and 3) decrease of HDL-C of ≥5% (n=193). The relations between the change in HDL-C and the change in monocyte count were analyzed. Results: A significant inverse relation between the change in HDL-C level and the change in monocyte count was found among the 3 study groups by 1-way analysis of variance (p=0.002). Subjects with increased HDL-C had significantly decreased monocyte count at the second check while subjects with decreased HDL-C had increased monocyte count. Multivariate regression analysis of data from all subjects revealed that the change of HDL-C was independently associated with a significant inverse change in monocyte count (p=0.007). Conclusions: In view of the documented inflammatory nature of atherosclerosis, the inverse relation between the change of HDL-C level and the change of monocyte count may partly explain why a higher serum HDL-C level can protect arteries against atherosclerosis.
延伸閱讀
- 黃詩涵（2018）。Investigate the characteristics of low-density lipoprotein from rheumatoid arthritis patients for a pilot study of cardiovascular complications〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-2308201810062900
- Ou, C. Y., Tseng, Y. F., Lee, C. L., Chiou, Y. H., & Hsieh, K. S. (2009). Significant Relationship between Serum High-sensitivity C-Reactive Protein, High-density Lipoprotein Cholesterol Levels and Children With Kawasaki Disease and Coronary Artery Lesions. Journal of the Formosan Medical Association, 108(9), 719-724. https://www.airitilibrary.com/Article/Detail?DocID=09296646-200909-108-9-719-724-a
- Khan, S. H., Fazal, N., Shah, A. A. G., Manzoor, S. M., Asif, N., Ijaz, A., Niazi, N. K., & Yasir, M. (2017). Correlation between Cholesterol, Triglycerides, Calculated, and Measured Lipoproteins: Whether Calculated Small Density Lipoprotein Fraction Predicts Cardiovascular Risks. Journal of Lipids, 2017(), 1-9-007. https://doi.org/10.1155/2017/7967380
- Huang, Y. C., Cheng, Y. W., Wu, V. C. C., Lin, C. P., Kao, Y. W., Chu, P. H., & Lin, Y. S. (2022). Lipoprotein(a) is Associated with Cardiovascular Events in Low Risk Males: Results from a Health Checkup Cohort with Long-Term Follow-Up. Acta Cardiologica Sinica, 38(3), 381-390. https://doi.org/10.6515/ACS.202205_38(3).20211225A
- Endo, A., Sato, H., Kagawa, Y., Kawahara, H., Morita, Y., Yasuda, Y., Pak, M., & Tanabe, K. (2021). The Effectiveness of Target Low-Density Lipoprotein Cholesterol Achieved with Strict Management in Secondary Prevention of Long-Term Coronary Events in Japanese Patients. Acta Cardiologica Sinica, 37(1), 65-73. https://doi.org/10.6515/ACS.202101_37(1).20200716A