- 期刊
- Ahead-of-Print
Dietary fiber intake is associated with chronic kidney disease (CKD) progression and cardiovascular risk, but not protein nutritional status, in adults with CKD
並列摘要
Background and Objective: Evidence suggests that dietary fiber benefits patients with chronic kidney disease (CKD); however, this conclusion requires further validation. In this study, we examined the effects of dietary fiber on kidney function, inflammation, indoxyl sulfate, nutritional status, and cardiovascular risk in patients with advanced CKD. Methods: In a cross-sectional study, we performed linear regressions to assess the association between dietary fiber intake and CKD parameters by using a retrospective Food Frequency Questionnaire (FFQ). In a longitudinal cohort study, the aforementioned parameters were compared over an 18-month follow-up period. Kaplan-Meier analysis was used to investigate the association between fiber intake and Cardiac vascular disease (CVD) by using prospective dietary records. Results: In total, 157 patients were included in this study. In the cross-sectional study, dietary fiber and inflammatory indices were associated (interleukin [IL]-6: β=−0.024, p=0.035). In the longitudinal study, the differential estimated glomerular filtration rate (ΔeGFR) as well as levels of C-reactive protein, IL-6, indoxyl sulfate, and serum cholesterol in the higher fiber intake (≥25 g/day) group were lower than those in the lower fiber intake (＜25 g/day) group (p＜0.05). Differences in IL-6 and indoxyl sulfate levels were more significant in patients in the higher protein intake group (p＜ 0.05). Dietary fiber intake may be a protective factor associated with CVD (hazard ratio=0.537 and 0.305-0.947). The protein nutritional status was not different between the two groups in the cross-sectional and longitudinal studies (p＞0.05).Conclusions: Our results suggest that increasing fiber intake can retard the decrease in the eGFR; can reduce the levels of proinflammatory factors, indoxyl sulfate, and serum cholesterol; and is negatively associated with cardiovascular risk, but does not disrupt the nutritional status of patients with CKD.
延伸閱讀
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