Fibroblast Growth Factor-23 and Phosphorus Related Factors in Young Japanese Women: A Cross-Sectional Study

Sanae Ito ； Hiromi Ishida ； Kazuhiro Uenishi

《Asia Pacific Journal of Clinical Nutrition》 預刊文章 Pp. 120-132

https://doi.org/10.6133/apjcn.092015.22

並列摘要

Phosphorus homeostasis is determined by dietary intake, intestinal absorption, and renal tubular reabsorption of phosphorus. Serum fibroblast growth factor-23 (FGF-23) is considered to be a sensitive early biomarker of disordered phosphorus metabolism in both patients with chronic kidney diseases and healthy subjects. However, the number of studies evaluating serum FGF-23 levels in healthy subjects is limited. The objective of this cross-sectional study was to examine the relationship between serum FGF-23 levels and phosphorus related factors in 182 young Japanese women (mean age, 19.5±0.4 years). We found that higher serum levels of inorganic phosphorus and lower serum levels of 1,25-dihydroxyvitamin D as well as lower fat but higher phosphorus and calcium intake were weakly but significantly associated with high serum levels of FGF-23, adjusted for postmenarcheal age and body weight. These results suggested that in young Japanese women, serum FGF-23 might be indicative of phosphorus nutrition status. However, it is worthy of note that maturity factors, including postmenarcheal age and physical attributes, such as body weight, might be related to serum FGF-23 levels.

並列關鍵字

fibroblast growth factor-23 ； phosphorus ； calcium ； bone mineral density ； young Japanese women