- 期刊
- Ahead-of-Print
Garlic Intake Lowers Fasting Blood Glucose: Meta-Analysis of Randomized Controlled Trials
並列摘要
Garlic is a common spicy flavouring agent also used for certain therapeutic purposes. Garlic's effects on blood glucose have been the subject of many clinical and animal studies, however, studies reporting hypoglycemic effects of garlic in humans are conflicting. A comprehensive literature search was conducted to identify relevant trials of garlic or garlic extracts on markers of glycemic control [fasting blood glucose (FBG), postprandial glucose (PPG), glycosylated hemoglobin (HbA1c)]. A meta-analysis of the effect of garlic intake on human was done to assess garlic's effectiveness in lowering glucose levels. Two reviewers extracted data from each of the identified studies. Seven eligible randomized controlled trials with 513 subjects were identified. Pooled analyses showed that garlic intake results in a statistically significant lowering in FBG [SMD=-1.67; 95% CI (-2.80, -0.55), 〞p〞=0.004]. Our pooled analyses did not include PPG control and HbA1c outcomes. Because only 1 study included in the meta-analysis reported PPG variables and only 2 studies reported HbA1c variables. In conclusion, the current meta-analysis showed that the administration of garlic resulted in a significant reduction in FBG concentrations. More trials are needed to investigate the effectiveness of garlic on HbA1c and PPG.
延伸閱讀
- Wahhab, K. G. E. D. A., Khadrawy, Y. A., & Mannaa, F. A. E. (2012). Aged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in CCl_4^- intoxicated rats. Comunicata Scientiae, 3(1), 55-63. https://www.airitilibrary.com/Article/Detail?DocID=21775133-201203-201605200013-201605200013-55-63
- Tsai, L. J., Wu, Y. F., Kuo, K. L., Tai, Y. S., & Lin, K. Y. (2017). Prediction of impaired fasting glucose: a retrospective cohort study. 輔仁醫學期刊, 15(4), 179-189. https://doi.org/10.3966/181020932017121504002
- 譚雅萍（2007）。Effects of garlic oil on oxidative stress and insulin secretory function in pancreas of STZ-induced diabetic rats.〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2007.00094
- Lin, Y. E., Lin, M. H., Yeh, T. Y., Lai, Y. S., Lu, K. H., Huang, H. S., Peng, F. C., Liu, S. H., & Sheen, L. Y. (2022). Genotoxicity and 28-day repeated dose oral toxicity study of garlic essential oil in mice. Journal of Traditional and Complementary Medicine, 12(6), 536-544. https://doi.org/10.1016/j.jtcme.2022.05.001
- 劉姚伶、謝孟志、鄭心嫻、謝明哲（1997）。The Influences of Garlic on Growth, Antioxidative Effect, and Lipid Metabolism in Hamsters。中華民國營養學會雜誌，22(4)，385-398。https://doi.org/10.6691/JCNS.199711_22(4).0003