Objectives: Constipation affects up to 20% of the world’s population. The aim of this study was to investigate whether supplementation with 〞Ficus carica〞 paste could be used to treat constipation in Korean subjects with functional constipation. Methods: We conducted a randomized, double-blind, placebo-controlled trial. Subjects with functional constipation were orally supplemented with either 〞F. carica〞 paste (n=40) or placebo (n=40) for 8 weeks. We measured the efficacy and safety of 〞F. carica〞 paste. Primary outcomes (colon transit time) and secondary outcomes (questionnaire related to defecation) were compared before and after the 8-week intervention period. Results: 〞F. carica〞 paste supplementation was associated with a significant reduction in colon transit time and a significant improvement in stool type and abdominal discomfort compared with the placebo. Blood parameters and clinical findings for organ toxicity remained within normal ranges. Conclusion: These results suggest that 〞F. carica〞 paste may have beneficial effects in subjects suffering from constipation.
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