Obesity risk and preference for high dietary fat intake are determined by FTO rs9939609 gene polymorphism in selected Indonesian adults

Mulianah Daya ； Dwi Ari Pujianto ； Fiastuti Witjaksono ； Lidwina Priliani ； Jimmy Susanto ； Widjaja Lukito ； Safarina G Malik

《Asia Pacific Journal of Clinical Nutrition》 28卷1期 (2019/03) Pp. 183-191

https://doi.org/10.6133/apjcn.201903_28(1).0024

摘要

Background and Objectives: Data suggest that genetic factors are associated with BMI. The fat mass and obesity-associated (FTO) gene modulates adipogenesis through alternative splicing and m6A demethylation. Individuals with FTO rs9939609 gene polymorphism have a preference for energy-dense foods. This study investigates the relationship between FTO rs9939609 and obesity and preference for dietary fat intake among selected Indonesian adults. Methods and Study Design: A total of 40 non-obese and 40 obese participants aged 19-59 living in Jakarta were recruited. Body composition measurements included body weight, height, BMI, waist circumference, and body fat mass. Dietary intake was assessed using a semiquantitative food frequency questionnaire and food recall over 2 × 24-h periods. Genetic variation was determined using amplification-refractory mutation system polymerase chain reaction. Results: The genotype distribution of the FTO gene (rs9939609) was at Hardy- Weinberg equilibrium (p=1) with minor allele frequency=0.19. Individuals with AT/AA genotypes had 3.72 times higher risk of obesity (p=0.009) and 5.98 times higher dietary fat intake (p=0.02) than those with TT genotype. Obese participants with the AT/AA genotypes had 1.40 times higher dietary fat intake than those with the TT genotype (p=0.016). Conclusions: These findings suggest that Indonesian adults with AT/AA genotypes of the FTO rs9939609 have higher obesity risks and preferences for high dietary fat intake than those with TT genotype.

關鍵字

obesity ； dietary fat intake ； FTO rs9939609 ； polymorphism ； Indonesian