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Introduction: Severe hypersensitivity reactions of lamotrigine are very uncommon conditions. "We present this case of rapid development of toxic epidermal necrolysis. Case Report: A 37year- old female of bipolar affective disorder on lamotrigine presented with acute skin eruptions with fever which involved almost whole body in next 7-10 days. There was massive peeling of the skin involving more than 50% of the body surface. Discussion: The case was diagnosed as lamotrigine induced toxic epidermal necrolysis and treated conservatively. Conclusion: "Watchfulness of the clinicians and educating the patient about the doses schedule and adverse reaction of lamotrigine is key to prevent severe cutaneous reactions.

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