Objectives: Although several surgical techniques for midclavicular fractures have been reported, Knowles pinning has rarely been compared with plating. The purpose of this study is to compare the clinical results of these two alternative techniques. Patients and methods: Between 2000 and 2003, 112 patients with midclavicular fractures were surgically treated with either Knowles pins or plates. Twelve to 24 months postoperatively, the clinical results were evaluated by a popular shoulder scoring system. A Student t-test was used for comparison of shoulder score, operating time, wound size, and hospital stay. The Pearson chi-square test was used for analysis of healing rate, complication rate, frequency of symptomatic hardware, and rate of elective hardware removal. Results: In the Knowles pin group, all fractures (100%) healed in 6 months. In the plate group, 32 of 33 fractures (97%) healed in 6 months (p=0.3). The mean shoulder scores of the Knowles pinning and plating groups were 93±4.3 points and 95±3.8 points, respectively (p=0.72). Knowles pinning required significantly shorter operation time (p<0.001), smaller wound size (p<0.001), shorter hospital stay (p=0.04), and was associated with less symptomatic hardware (p<0.001) and lower complication rate (p=0.024). Conclusion: If surgery of mid-third clavicular fractures is indicated, fixation with a Knowles pin has more advantages than plate fixation.