Extended-Interval Dosing Regimen of a Triptorelin Depot in the Treatment of Advanced Prostate Cancer

Triptorelin Depot延長使用間隔，在前列腺癌病患的治療成果報告

莊光達(Guang-Dar Juang) ； 黃一勝(Thomas I-Sheng Hwang)

《臺灣泌尿科醫學會雜誌》 16卷2期 (2005/06) Pp. 45-52

摘要

研究目的：晚期前列腺癌的病患使用性腺激素釋放相似物(LHRH)做內分泌治療，目前大都是使用每四週注射一次的長效型劑型。本研究是探討是否可將四星期注射一次triptorelin depot的時間延長為六星期注射一次，在維持抑制男性荷爾蒙的效性及成本的評估。
材料與方法：從2001年5月至2003年6月，共有十三位晚期前列腺癌的病患先以每四星期注射一次triptorelin depot共四劑後，待血清男性荷爾蒙被抑制至閹割的程度之後，將注射的時間延長為六星期注射一次，再給予六個劑量triptorelin depot在這五十四星期的研究期間，檢查血清PSA testosterone和luternizing hormone(LH)的變化。
結果：注射triptorelin depot一個月之後有76.9%的病患，而3個月後全部病患血清中男性荷爾蒙的濃度下降至閹割的程度，而往後五十四星期的研究期間，雖然延長注射期間為6星期tripotorelin depot在男性荷爾蒙抑制的維持方面，效果很好，而PSA的控制方面，PSA維持在＜0.5ng/ml的效果佔76.9%的病患。
結論：從我們初步的研究報告得知，用triptorelin depot在治療前列腺癌的病患在達到血清中男性荷爾蒙閹割程度之後，將注射時間延長為六星期和常規的每四星期注射一次，在維持抑制testosterone及PSA上升的效果方面是沒有差別的。

關鍵字

triptorelin depot ； 性腺激素釋放相似物 ； 前列腺癌

並列摘要

Objective: Gonadotrophin-releasing hormone (LHRH) analogues are commonly used in the treatment of advanced cancer of the prostate. Depot administration every 4 weeks is a well-established regimen worldwide. An extended 6-week dosing regimen of a triptorelin depot in patients with prostate cancer (PC) to maintain castration was evaluated for its efficacy and cost-effectiveness.
Materials and Methods: From May 2001 through June 2003, 13 patients with advanced PC were given 4 doses of a triptorelin depot of 3.75 mg intramuscularly every 4 weeks, followed by 6 more doses of a triptorelin depot at 3.75 mg at 6-week intervals. Serum prostate-specific antigen (PSA), testosterone, and luteinizing hormone (LH) were measured before and after the serial injections of the triptorelin depot.
Results: Castration testosterone levels were achieved in 76.9% and 100% at 1 and 3 months after treatment, respectively. Castration testosterone levels were maintained for 54 weeks in all patients given the extended-interval schedule of the triptorelin depot. PSA levels of less than 0.5ng/ml were observed in 76.9% (10/13) of patients at the end of this study.
Cosclusions: The extended 6-week triptorelin depot injection schedule was as effective as the 4-week schedule for maintenance of serum PSA, LH, and testosterone at castration levels in our patients with advanced PC; extended-interval dosing contributed to a 1/3 reduction in treatment costs, without compromising the therapeutic efficacy among our patients.

並列關鍵字

triptorelin depot ； GnRH agonist ； prostate cancer