We analyzed 2 cases of small cell carcinoma of the prostate. One patient had pure small cell carcinoma with multiple organ metastasis, while the other had a mixed-type carcinoma. The immunohistochemical studies revealed positive reactions to chromogranin A, synaptophysin, and cytokeratin stains, and negative for PSA stain over both small cell carcinoma foci. These 2 patients were immediately treated, and partial resolution of the previous metastatic bone lesions was noted after receiving 5 courses of chemotherapy with the combination of gemcitabine, carboplatin, and irradiation therapy in case 1, while adjuvant irradiation was scheduled for case 2.