上頜骨之骨肉瘤

上頜骨骨肉瘤為文獻中罕見之疾病，顏面部骨肉瘤僅佔頭頸部惡性腫瘤的1%，好發於30~40歲的年紀，其病理特徵可分4大類，腫瘤於影像上亦有特殊的表現。治療方式以手術切除為主，唯局部復發率高達80%，其致死原因多為顱內侵犯。病患的預後因子包括腫瘤位置、轉移及是否合併Padget disease。在基因及分子生物學方面，可發現顏面部骨肉瘤之特性。本文報告一18歲男性上頜骨骨肉瘤，於根除性手術及化學、放射治療後已逾6年，迄今未復發，故提出報告並回顧文獻。

關鍵字

骨肉瘤；上頜骨

並列摘要

Reports regarding osteosarcoma of the maxilla are rare. Craniofacial osteosarcoma accounts for approximately 1% of all head and neck neoplasms and occurs predominantly during the 3rd and 4th decade of life. Histologically, osteosarcoma can be divided into four major types, each presenting with its own particular features. The development of osteosarcoma has been reported to be associated with risk factors, such as exposure to radiation, Paget's disease, fibrous dysplasia, and retinoblastoma. Surgical resection is the treatment of choice. Osteosarcoma with intracranial invasion has a high recurrence rate (80%) and is also associated with a high mortality rate. However, considerable improvement in survival can be achieved by chemotherapy. Known prognostic factors include tumor sites, metastasis and Padget disease. In this report, we presented an 18-year-old male patient with maxillary osteosarcoma. After treatment by us, he has been disease-free for 6 year and is still receiving regular follow-up. In this case report we want to share our positive experiences with this patient and the treatment of osteosarcoma as well as reviewing previous studies.

並列關鍵字

osteosarcoma ； maxilla

國際替代計量

上頜骨之骨肉瘤

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