A 52-year-old man underwent 18F-FDG positron emission tomography (FDG PET) scan as part of a physical check-up. FDG PET scan revealed a focal high uptake in the rectum at 1 hr after injection of FDG. Delayed 3-h imaging was performed after enema and it showed no change in the lesion. The diagnosis of this lesion was internal hemorrhoids based on sigmoidoscopy. After a 6-month-follow-up, the patient was doing well. To our knowledge, the high level of FDG uptake in a hemorrhoid has not yet been reported.
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