以尿液cotinine濃度評估自塡式吸菸問卷的準確度與不同吸菸模式之相關性

Evaluation of the Accuracy of Self-reported Smoking Questionnaire and Correlation among Different Smoking Models-Based on Cotinine Concentration in Urine

楊燦(Tsan Yang) ； 李子平(Tzu-Ping Li) ； 祝年豐(Der-Min Wu) ； 吳德敏(Chien-An Sun) ； 孫建安(Cha-Mein Chen) ； 陳家勉(Wei-Kang Chang) ； 張維剛(Shu-Anne Yang)

《中華職業醫學雜誌》 12卷4期 (2005/10) Pp. 255-265

https://doi.org/10.30027/CJOM.200510.0006

摘要

近年來台灣吸菸人口不斷地增加，香菸消耗量持續上升，而吸菸對於人的健康而言，已被全世界公認為主要危險因子之一。根據許多研究資料指出，許多慢性心血管疾病、呼吸系統疾病、癌症等，與吸菸有密切的因果關係。然而在菸害研究一般仍需透過問卷填答，而對其填答準確性有需要加以評估。本研究即是以尿液可丁尼(cotinine)濃度評估自填式吸菸問卷的準確度與不同吸菸模式之相關性探討。結果顯示，尿中cotinine濃度與是否抽菸達統計上顯著差異。目前仍吸菸者尿中cotinine濃度顯著高於從不吸菸者，戒菸者也比從不吸菸者有較高的尿中cotinine濃度。cotinine濃度以300ng/ml為切點其敏感度、特異度分別為96.7%、90.5%。經由卡方檢定的結果顯示尿中cotinine濃度分組與是否抽菸有關，且尿中cotinine濃度分組與吸菸支數（量）有關，均達顯著差異。將香菸吸入肺部程度與尿中cotinine濃度相關性探討，結果顯示，並未達到顯著影響，但是仍發現，經常將香菸吸入肺部者有較高的cotinine濃度。因此，本研究以尿中cotinine濃度評估自填式問卷有關吸菸行為顯示有良好的準確度。

關鍵字

可丁尼濃度 ； 吸菸行為 ； 準確度

並列摘要

Cigarette smoking is a leading cause of preventable death. Over the past decades, hundreds of epidemiological researches have been found strong associations between smoking and a variety of diseases. Currently, the majority of research on the adverse effects of smoking and on smoking behavior relies on the collection of questionnaire data. The aims of this study were to evaluate of the accuracy of self-reported smoking questionnaire and correlation among different smoking models. A total of 155 male workers who agreed to participate in this smoking questionnaire survey were recruited. This study determines the cut-off point for smoking as cotinine concentration in urine of 300 ng/ml. The results revealed relative sensitivity and specificity of 96.7% and 90.5% respectively. The Chi-square test showed that cotinine concentration in urine was significantly related to the smoking behavior. The results of this study clearly revealed that the concentration of cotinine in urine was consistent with the results of smoking behavior, degree of nicotine dependence and degree of smoke inhalation into the lungs, as a result, the cotinine concentration in the urine was a good biomarker.

並列關鍵字

Cotinine concentration ； Cigarette smoking ； Smoking behavior