- 期刊
Hypertrophic Osteoarthropathy (HOA) as the Initial Presentation of Squamous Cell Carcinoma of the Lung: A Case Report
以肥厚性骨頭關節病變(hypertrophic osteoarthropathy，HOA)爲初始表現之肺鱗狀上皮細胞癌－病例報告
摘要
肥厚性骨頭關節病變(hypertrophic osteoarthropathy, HOA)是一包含杵狀指、骨膜炎及關節炎之臨床徵候。大多數之肥厚性骨頭關節病變是次發性的，大部份跟惡性腫瘤有關，尤其是肺部的惡性腫瘤。肥厚性骨頭關節病變之成因被認為是跟血小板、血管內皮生長因子(vascular endothelial growth factor, VEGF）、血小板衍生性生長因子(platelet-derived growth factor, PDGF)等有關。肥厚性骨頭關節病變之治療須針對其原發疾病作治療。這裡我們提出一個33歲之女性，一開始表現出杵狀指及關節炎，經過詳細檢查後診斷為肺鱗狀上皮細胞癌之病人。經過化學治療後病人之肥厚性骨頭關節病變明顯改善。
並列摘要
Hypertrophic osteoarthropathy (HOA) is a clinical syndrome consisting of periostitis, arthritis and clubbing. HOA is associated with a variety of diseases, the malignancies of which are the major cause, especially pulmonary malignancies. The mechanism of HOA may be associated with platelets, VEGF, PDGF, or other cytokines. The therapy for HOA should be directed at the underlying disease. We herein report the case of a 33-year-old woman who suffered from squamous cell carcinoma of the lung with the initial presentation of arthritis and clubbing. The symptoms of HOA resolved after 6 courses of chemotherapy and curative radiotherapy.
延伸閱讀
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