Hyperfractionated Radiotherapy of Lung Cancer: Report of a Pilot Study

肺癌的多分次放射治療：初步報告

任益民(Yee-Min Jen) ； 許文林(Wen-Lin Hsu) ； 吳錦榕(Ching-Jung Wu) ； 熊佩韋(Pei-Wei Shueng) ； 蘇志中(Chih-Chung Su) ； 黃經民(Jing-Ming Hwang) ； 張東浩(Tung-Hao Chang)

《放射治療與腫瘤學》 2卷2期 (1995/06) Pp. 123-129

https://doi.org/10.6316/TRO/199502(2)123

摘要

本文目的，在於評估以多分次放射線照射法治療局部晚期或不能手術之肺癌病人是否可行、病人是否可以耐受該種放療。目前有十三個病人接受此種照射方式，除一例為小細胞肺癌之外，餘皆為非小細胞肺癌。年齡介於37至84歲之問，十三人中便有十二人大於60歲。除了一例為T2N0M0的早期病人是由於內科理由無法手術之外，其他病例均為局部晚期或復發”照射方法為120 cGy bid，縱膈腔接受4,200-4,500 cGy，原發腫瘤為7,000 cGy。最短及最長追蹤期分別為1及34個月。七個病人於照射中發生吞嚥疼痛或喉嚨痛：啞心嘔吐僅偶爾出現且均甚輕微。放射性肺炎是惟一經常出現的晚期副作用，有十一個病人於照射結束後需要藥物治療嚴重咳嗽或呼吸不暢。共有十個病人需要使用類固醇。有六個病人出現持續超過六個月之久的肋膜積水。所有以上副作用均能處理，且並無病人因放射性肺炎而住院“在腫瘤對照射的反應方面，兩例為完全反應、十一例為部份反應或穩定。目前局部復發的有兩例、已發生遠處轉移的有五例。
總結而言，使用120 cGy bid及7,000 cGy的照射法，病人耐受力及局部控制率均佳，且在臨床上也方便易行。

關鍵字

肺癌 ； 多分次放射治療

並列摘要

The purpose of the present paper is to evaluate the feasibility and patient tolerance of hyperfractionated radiotherapy in advanced or inoperable lung cancer patients. Thirteen patients, all of non-small cell lung cancer (NSCLC) except one, were treated with 120 cGy bid hyperfractionated radiotherapy. The age range were between 37 and 84 years, with 12 of them older than 60. Except one medically inoperable T2N0M0 patient, all the remaining 11 NSCLC patients were either locally advanced or had local-regional recurrence. Patients received 4200-4500 cGy to the mediastinum and 7000 cGy to the primary lesion. Minimum and maximum follow-up was 1 and 34 months, respectively. Seven patients developed dysphagia/sore throat during irradiation. Nausea/vomiting was infrequent and mild. Radiation pneumonitis was the single significant chronic side effect up to the time of analysis. Eleven patients required some medication during the post-radiotherapy period for either severe cough or dyspnea. Ten needed steroid. Chronic pleural effusion that persisted for more than 6 months was observed in 6 patients. This was manageable in all patients. No patient was hospitalized because of radiation-induced pneumonitis. There were 2 CR and 11 PR/SD. Local recurrence has developed in 2. Distant metastasis has been documented in 5 patients who were initially MO. Patient tolerance and local control were good. Hyperfractionated radiotherapy, 120 cGy bid, with a total dose of 4500 cGy to the mediastinum and 7000 cGy to the primary lesion, is a feasible and tolerable regimen for lung cancer patients.

並列關鍵字

Lung cancer ； Hyperfractionated radiotherapy