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  • 期刊

局部重度非小細胞肺癌之多種型式治療

Multimodality Treatment of Locally Advanced Non-Small Cell Lung Cancer

摘要


對於早期局限性的非小細胞肺癌,由於化療效果不太理想,因此外科切除是主要的選擇。但已有轉移者,則只好以化療作姑息性或試驗性的治療。如果是局部重度非小細胞肺癌,對於如何治療,則仍有爭議。因為單一外科切除或放療,效果都不理想,所以應考慮多型式療法。問題是如何配合手術、放療及化療,而化療中應以何種藥物,則是各有不同意見。本文就以此一問題,作一簡要的綜合討論,以供參考。目前各方面的臨床試驗結果,證明多型式治療,對局部重度非小細胞肺癌患老是可行而又有好處的,尤其是對一般狀況較好的病患。所以應該往此方向發展,同時更讓我們感覺到,併用化療與放療對局部控制有好處,而依序化療與放療,可減少轉移。然而距離我們的理想還遠。因此,期待新藥的開發。

並列摘要


Surgical resection is the main treatment for stage I, II non-small cell lung cancer (NSCLC). Combination chemotherapy programs or others are the principle palliative treatment for metastatic stage IV disease. Controversies exist in localized advanced stage III a and III b NSCLC. Different approaches including neoadjuvant chemotherapy followed by surgery, induction chemotherapy with sequential radiotherapy, different schedules of primary radiotherapy, concomitant chemotherapy and radiotherapy have been reviewed in this article. The optimal treatment for stage III b NSCLC may be concomitant chemotherapy and radiotherapy than either radiotherapy alone or sequential chemotherapy and radiotherapy. However, more clinical trials is warrant.

並列關鍵字

Multimodality treatment Lung cancer NSCLC

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