Small Cell Neuroendocrine Carcinoma of Ethmoid Sinus: Case Report and Literature Review

篩骨腔小細胞神經內分泌癌：病例報告及文獻回顧

林逢嘉(Forn-Chia Lin) ； 林立青(Li-Ching Lin) ； 蘇正川(Chang-Chuan Su) ； 林奎利(Kuei-Li Lin) ； 郭珍妮(Jenny Que)

《放射治療與腫瘤學》 10卷3期 (2003/09) Pp. 175-179

https://doi.org/10.6316/TRO/200310(3)175

摘要

副鼻竇腔惡性腫瘤佔人類所有惡性腫瘤的0.2到0.8%，鱗狀細胞癌是最常見的組織型態，原發篩骨腔小細胞神經內分泌癌是一罕見且惡性之腫瘤，其組織型態及免疫化學染色特徵與肺小細胞癌相似；臨床上需併用手術或放射治療及化學治療等方式處理。
我們報告一位原發篩骨腔小細胞神經內分泌癌的案例，腫瘤侵犯至右眼窩內側及上顎鼻竇腔；於腫瘤摘除術後輔以放射治療及化學治療。追蹤至今約六個月，並無局部復發或遠端轉移情況發生。文中另探討小細胞神經內分泌癌之最適當處理模式及其免疫化學染色特徵。

關鍵字

小細胞神經內分泌癌 ； 篩骨腔 ； 放射治療

並列摘要

Malignant tumors arising in the paranasal sinuses account for 0.2 to 0.8% of all cancers. Squamous cell carcinoma is by far the most common malignant tumor. Primary small cell neuroendocrine carcinoma of ethmoid sinus is an uncommon and distinctive tumor with an aggressive clinical behavior. Besides, its morphological and immuno-histo-chemical features are similar to those of small cell carcinoma of lung. The need for a multi-disciplinary treatment approach combining surgery or radiotherapy and chemotherapy is indicated in treating these aggressive tumors.
We report a case of 40-year-old man who has small cell neuroendocrine carcinoma of ethmoid sinus with invasion of upper aspect of right maxillary sinus and medial aspect of right orbit. The patient was treated with surgery and adjuvant radiotherapy followed by systemic chemotherapy. Neither local recurrence nor distant metastasis was noted during follow-up of 6 months. The optimal treatment and the immuno-histo-chemical characteristics are discussed.

並列關鍵字

Small cell neuroendocrine carcinoma ； Ethmoid sinus ； Radiotherapy