生長因子在癒合不良傷口之臨床應用初步報告

Clinical Application of Growth Factor in Poor Healing Wounds: Preliminary Report

王邦元(Pong-Yuen Wong) ； 黃美涓(May-Kuen Wong) ； 陳家禎(Chia-Chen Chen)

《中華民國復健醫學會雜誌》 17期 (1989/12) Pp. 70-74

摘要

本研究利用生長因子使用於8位傷口癒合不良的病患身上，觀察其對於傷口之癒合是否有促進作用。結果顯示，傷口均能完全癒合。而使用當中，未有任何傷口產生過敏，感染或變壞等情況，而病患亦無任何不適症狀，顯示生長因子對促進慢性癒合不良傷口之癒合速度有所幫助，值得作進一步探討及推廣。

並列摘要

Growth factor was reported to be effective in promoting wound healing, possibly through the mechanisms of stimulating DNA synthesis, chemotaxis of fibroblasts, embryogenesis, angiogenesis and enhancement of epithelialization. For investigation of the clinical result, 8 cases with poor healing wounds were treated by our own product of ointment with growth factor. They were admitted to Chang Gung Memorial Hospital from Feb. to December 1988. Among them, three were DM foot complicated with peripheral vascular disease and received below- knee amputation, three were sacrum pressure sore, and two were traumatic injury with extensive skin defect. All of these patients had received conventional wound care for a period of time or with skin graft, but resulted in poor wound healing.
After the application of growth factor to those wounds, all of them had remarkable improvement, and were healed within 3 weeks to 102 days. There were no any noxious complication such as inflammation, infection, allergy, local irritation, or with any systemic side effect. From this preliminary clinical application study, growth factor is proved to be very effective even in poor healing wounds, suggesting enough benefits to expand to a larger study of further research.

並列關鍵字

growth factor ； wound healing ； pressure sore