以前列腺素E1作海線體注射治療脊髓損傷患者勃起障礙之初步經驗

Intracavernous Injection of Prostaglandin E1 in Spinal Cord Injured Patient with Erectile Dysfunction: A Preliminary Report

鄧復旦(Fuk-Tan Tang) ； 王邦元(Pong-Yuen Wong) ； 黃美涓(May-Kuen Wong)

《中華民國復健醫學會雜誌》 20期 (1992/12) Pp. 49-53

https://doi.org/10.6315/JRMA.199212.0006

摘要

本研究以民國80年5月至11月間因脊髓損傷合併勃起障礙的7位病患為對象，探討以前列腺素E1（PGE1）作陰莖海綿體注射後，對於陰莖勃起所需的時間、硬度、勃起持續時間及射精等各方面之影響。結果顯示，7位病患均可達到至少半小時以上的完全勃起，有三位病患可完成射精，並有一位病患的妻子懷孕，而且使用期間並無明顯之系統性及局部之副作用。由此可見PGE1對於治療因脊髓損傷所引起之神經性勃起障礙效果良好，值得繼續研究及推廣使用。

關鍵字

spinal cord injury ； sexual dysfunction ； intracavernous injection

並列摘要

Sexual dysfunction with inadequate or poorly sustained erection is a common problem among spinal cord injured patients although reflex erection may be preserved in upper motor neuron lesion and lower motor neuron and psychogenic erection may be preserved in incomplete lesion respectively. Methods to restore erection, such as vaccum tumescense constriction therapy and penile prostheses may be useful but potentially have adverse effects. Recently, intracavernous injection of prostaglandin E1 has been found beneficial to patients with neurogenic erectile dysfunction.
In our study, we administered intracavernous injection of prostaglandin E1 (PGE1), 15 μ g, to seven patients with neurogenic erectile dysfunction due to spinal cord injury from May 1991 to November 1991 at chang Gung Memorial Hospital. Full erections sustaining at least thirty minutes following injections of PGE1 were seen in all of these patients while ejaculation in three patients and conception in one case were noted. No priapism, systemic reaction, nor fibrosis of cavernous tissue or scar formation was observed after thirty injections. From this preliminary clinical study, intracavernous injection of PGE1 is effective to neurogenic erectile dysfunction after spinal cord injury.