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成人院內念珠菌血流感染流行病學特徵之分析

An Analysis of Nosocomial Candidemia among Hospitalized Adult Patients

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摘要


A retrospective study was performed to investigate predisposing factors, clinical manifestations, and prognosis of adult patients with nosocomial candidemia at Kaohsiung Medical University Hospital, from January, 1998, till September, 2000. There was a total of 109 patients with the infection, with the prevalence of 1.32 per 1,000 discharges. The average age of patients was 61.9±15.9 years (median 64). There was no difference between the mcidences in the male and the female. The infection was 9.6 times more common in the intensive care units than in the regular wards (7.59% vs. 0.79%; p <0.001). Pre-infection hospital stay was 43.7±71.5 days (median 25), and the total hospital stay was 5-6 time longer than that of the average patients (82.1 ±128 days vs. 14±16 days; p<0.01). The infected cases had underlying haemato-oncologic diseases (47.7%), gastrointestinal diseases (38.5%), or diabetes mellitus (34.7%). The 3 most common invasive procedures applied during the pre-infection admission periods were the insertion of indwelling central venous catheters (76.1%), Foley catheters (66.1%), and endotracheal tubes (52.3%). During the same period, 82.6% were given more than 3 kinds of antibiotics, and 45% given H2 blockers. The most common pathogen was Candida albicans (43%), followed by C. tropicalis (20%), C. parapsilosis (7.3 %), and C. intermedia (6.4%). Antifungal agents were given to 86 patients to treat the infection. The mortality rate was 40.4%. The significant risk factors (p<0.05) included the old age (66.16±14.75 years), underlying haemato-oncologic diseases, cachexia, and septic shock.

並列摘要


A retrospective study was performed to investigate predisposing factors, clinical manifestations, and prognosis of adult patients with nosocomial candidemia at Kaohsiung Medical University Hospital, from January, 1998, till September, 2000. There was a total of 109 patients with the infection, with the prevalence of 1.32 per 1,000 discharges. The average age of patients was 61.9±15.9 years (median 64). There was no difference between the mcidences in the male and the female. The infection was 9.6 times more common in the intensive care units than in the regular wards (7.59% vs. 0.79%; p <0.001). Pre-infection hospital stay was 43.7±71.5 days (median 25), and the total hospital stay was 5-6 time longer than that of the average patients (82.1 ±128 days vs. 14±16 days; p<0.01). The infected cases had underlying haemato-oncologic diseases (47.7%), gastrointestinal diseases (38.5%), or diabetes mellitus (34.7%). The 3 most common invasive procedures applied during the pre-infection admission periods were the insertion of indwelling central venous catheters (76.1%), Foley catheters (66.1%), and endotracheal tubes (52.3%). During the same period, 82.6% were given more than 3 kinds of antibiotics, and 45% given H2 blockers. The most common pathogen was Candida albicans (43%), followed by C. tropicalis (20%), C. parapsilosis (7.3 %), and C. intermedia (6.4%). Antifungal agents were given to 86 patients to treat the infection. The mortality rate was 40.4%. The significant risk factors (p<0.05) included the old age (66.16±14.75 years), underlying haemato-oncologic diseases, cachexia, and septic shock.

並列關鍵字

nosocomial candidemia risk factor

被引用紀錄


宋佳穎(2005)。某醫學中心外科加護病房使用中心靜脈導管引起院內感染之相關因素探討〔碩士論文,中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834%2fCSMU.2005.00066
張雪梅(2005)。應用無針式密閉系統裝置於血液腫瘤病患中心靜脈導管照護上之成本與效益分析〔碩士論文,臺北醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0007-1704200714575017

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