探討第六型骨成形蛋白質對於骨礦化／牙周傷口癒合的影響

Effects of Bone Morphogenetic Protein-6 on the Bone Mineralization/Periodontal Wound Healing

林聖博(Sheng-Po Lin) ； 邱賢忠(Hsien-Chung Chiu) ； 沈一慶(E-Chin Shen) ； 傅鍔(Earl Fu) ； 江正陽(Cheng-Yang Chiang)

《臺灣牙周病醫學會雜誌》 22卷1期 (2017/03) Pp. 64-73

https://doi.org/10.6121/TAP.2017.22.1.07

摘要

從1965年Urist發現骨成形蛋白質（bone morphogenetic protein, BMP）可以促進異位性骨質新生後，至二十一世紀初期人類重組第二型與第七型骨成形蛋白質（recombinant human bone morphogenetic protein-2, -7, rhBMP-2, -7)已被允許應用於人體及醫療器材塗料促進骨折處癒合；如今，在許多文獻中已經發現人類重組第六型骨成形蛋白質（recombinant human bone morphogenetic protein-6, rhBMP-6）在刺激骨鈣素（osteocalcin, OCN）的分泌與骨母細胞分化（osteoblast differentiation）的效果比rhBMP-2和-7更為優異。因此本文就相關細胞與動物實驗做簡要的整理，探討BMP-6對於牙周傷口癒合的影響，以作為未來臨床治療和應用的參考。

關鍵字

骨成形蛋白質 ； 第六型骨成形蛋白質 ； 骨礦化 ； 牙周再生

並列摘要

Since the function of ectopic bone formation through the induction of BMPs was found by Dr. Urist in 1965, BMP-2 and -7 were allowed to apply on the coating of medical instruments and on human body to promote healing of bone fracture in the early twenty-first century. Moreover, the studies showed that BMP-6 was more superior in the synthesis of osteocalcin and osteoblast differentiation than BMP-2 and -7. Therefore, the purpose of this study is not only to introduce the history and related mechanism in target cells of rhBMP-6, but also to summarize the findings of both in vitro and in vivo studies of BMP-6 and discuss the possible study design in future research.

並列關鍵字

bone morphogenetic protein ； bone morphogenetic protein-6 ； bone mineralization ； periodontal regeneration