基因表達分析對早期乳癌婦女接受術後輔助性化療選擇之統合分析

蔡宜庭; 方素瓔

doi:10.6320/FJM.202205_26(3).0003

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P287 - 301

Health & Medical Care > General

DOI： 10.6320/FJM

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基因表達分析對早期乳癌婦女接受術後輔助性化療選擇之統合分析

The Effectiveness of Gene Expression Profiling on Decision Making for Adjuvant Chemotherapy in Women with Early-Stage Breast Cancer

蔡宜庭(Yi-Ting Tsai) ；方素瓔(Su-Ying Fang)

台灣醫學； 26卷3期 (2022 / 05 / 25) ， P287 - 301

繁體中文 DOI： 10.6320/FJM.202205_26(3).0003

早期乳癌；化學治療；基因表達分析檢測；決策衝突；系統性文獻回顧；統合分析； breast cancer ； chemotherapy ； gene expression profiling test ； decision conflict ； systematic review ； meta-analysis

Abstract │ Reference (34)

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Using adjuvant chemotherapy to prevent cancer recurrence in patients with early breast cancer is not absolute. With the development of precision medicine, gene expression profiling tests can be used as an indication for breast cancer patients to consider receiving chemotherapy. Inconsistent results on improving women's decision-making conflict required further examination. Systematic review and meta-analysis was conducted. The primary purpose was to 1) understand the effectiveness of gene expression profiling tests in the decision-making conflict about adjuvant chemotherapy for early breast cancer women, and 2) to examine the effectiveness of decision-making conflict according to the risk level by recurrence scores. The secondary purpose was examined the effectiveness of gene expression profiling tests on the state anxiety. Studies published before June 2021were searched. The database includes Embase, MEDLINE, Cochrane Library and other sources such as google scholar. Study quality was assessed using CASP (Critical Appraisal Skills Programme) and statistical analyses were performed using comprehensive meta-analysis version 2 software. A total of 11 studies were include, all of which were single-group pre and post-test studies. The results of meta-analysis showed that gene expression profiling tests can effectively improve decision-making conflicts (fixed mode SMD=-0.204, p＜0.001; random mode SMD=-0.224, p＜0.001) and state anxiety (SMD=-0.180, p＜0.001). Sub-group analysis showed that the improved decision-making conflict in the high-risk group was much more compared to the low-risk group. However, state anxiety decreased was only observed in the low-risk group.

Reference ( 34 ) 〈TOP〉

Cardoso F, Kyriakides S, Ohno S, et al. Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2019;30:1194-220.
連結：
Berry DA, Cirrincione C, Henderson IC, et al. Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. JAMA 2006;295:1658-67.
連結：
Coates AS, Winer EP, Goldhirsch A, et al. Tailoring therapies--improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015. Ann Oncol 2015;26:1533-46.
連結：
Rampurwala MM, Rocque GB, Burkard ME. Update on adjuvant chemotherapy for early breast cancer. Breast Cancer (Auckl) 2014;8:BCBCR-S9454.
連結：
Quinten C, Kenis C, Hamaker M, et al. The effect of adjuvant chemotherapy on symptom burden and quality of life over time; a preliminary prospective observational study using individual data of patients aged ≥70 with early stage invasive breast cancer. J Geriatr Oncol 2018;9:152-62.
連結：

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