Objectively Structured Clinical Examiniation (OSCE) was popularized as a test for clinical competence. The University of Santo Tomas Faculty of Medicine and Surgery, a large population medical school, used OSCE as part of the evaluation of students’ skills in the Art & Science of Medicine Module. This study aims to: 1) discuss the mini OSCE experience at the University of Santo Tomas faculty of Medicine and Surgery; 2) describe the effect of the mini OSCE in a large population university in terms of students’ performance and 3) analyze the variations in scoring by the faculty. Majority of the students performed well in the examination. The mean score of the students is 82.6%. ANOVA showed a variation in the scores given by faculty in each station. Issues related to its use such as validity, objectivity, practicality, choice of rater, standardization of patients, range of application, and reliability were taken into consideration. It is recognized that inter-rater reliability must be assessed. A series of OSCE examinations must be conducted in order to assess more skills and make the examination more generalizable.