Purpose: This paper describes our experience in integrating a patient safety and quality improvement program into the undergraduate medical education curriculum. Methods: We designed a 1-credit elective learning course, which integrates patient safety concept, quality management, and tools for continuous quality improvement (CQI), for fourth-year (pre-clerkship) medical students. Both classroom lectures and case-based interactive discussion activities on a case-scenario were taught in this learning course. We also made a website for facilitating learning or inquiry from students. A formative questionnaire to evaluate knowledge, skill, and attitude toward CQI as well as satisfaction to this learning course, was constructed. Results: Students' perception of knowledge and skill handling patient safety issues after this course were appropriate, with the former slightly higher than the latter. All students expressed a strong positive feedback to this course and will recommend this course to their colleagues and other students. In addition, teachers who participated in this course felt great fulfillment from interacting with students. Conclusion: Our program serving as an example of integrating patient safety and quality improvement program into undergraduate medical students is an effective way to expose future healthcare personnel earlier to the correct way of solving or dealing with patient safety issues.