運動對肥胖合併阻塞型睡眠呼吸中止症引發心臟功能損傷之影響：肌肉激素的角色

黃森芳; 陳聰毅

doi:10.6162/SRR.2015.135.06

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P67 - 77

Social Sciences > Physical Education

DOI： 10.6162/SRR

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運動對肥胖合併阻塞型睡眠呼吸中止症引發心臟功能損傷之影響：肌肉激素的角色

Effects of Exercise on Cardiac Dysfunction Induced by the Combination of Obesity and Obstructive Sleep Apnoea: The Role of Myokines

黃森芳(Sen-Fang Huang) ；陳聰毅(Tsung-I Chen)

大專體育； 135期 (2015 / 12 / 31) ， P67 - 77

繁體中文 DOI： 10.6162/SRR.2015.135.06

脂肪激素；發炎反應；纖維化；間歇性低氧； adipokine ； inflammation ； cardiac fibrosis ； intermittent hypoxia

Abstract │ Reference (42) │ Times Cited (1) │ Altmetrics

Abstract 〈TOP〉

Parallel Abstract 〈TOP〉

Obesity and intermittent hypoxia (IH) occurring during obstructive sleep apnoea (OSA) are two independent risk factors for impaired ventricular function; moreover, cardiac dysfunction is exacerbated when the two factors co-occur. Regular exercise provides beneficial effects to attenuate cardiac fibrosis by reducing body fat and preventing adipokine dysregulation. However, it is still unclear whether muscle-derived cytokines (myokines) released during exercise play a role in the prevention of IH-induced cardiac dysfunction. The purpose of this paper was to investigate the influence of myokines on the dysregulation of adipokines and reduction of ventricular dysfunction. The role that myokine plays in the effect of exercise on cardiac function in obese OSA patients was discussed within a literature review. The conclusion of this paper is that in obese individuals, excess adipose mass triggers dysregulation of adipokines, which leads to myocardial inflammation resulting in left ventricular dysfunction. Exercise induces an increase in energy expenditure, and also triggers the release of myokine into circulation by skeletal muscles, accelerating lipid metabolism and inhibiting the release of excess adipokines. This process helps alleviate myocardial inflammation and prevent the impairment of ventricular function. This paper suggests that future studies should investigate the effects of myokine on the lipid metabolism, including how to efficiently reduce fat deposition and alleviate inflammation. In effect, muscle-derived cytokines can be considered an anti-inflammatory medication. This provides support for advocating that regular exercise provides cardioprotective effects against the impairment of cardiac function in obese OSA patients.

Reference ( 42 ) 〈TOP〉

陳聰毅(2011)。罹患阻塞型睡眠呼吸中止症對運動能力的影響。中華體育季刊，25(1)，1-9。
連結：
陳聰毅、謝茜茹(2011)。運動對阻塞性睡眠呼吸中止症患者心肌氧化傷害的影響。大專體育，112，62-68。
連結：
Al-Daghri, N. M.,Alokail, M. S.,Rahman, S.,Amer, O. E.,Al-Attas, O. S.,Alfawaz, H.,Piya, M. K.(2015).Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2.European Journal of Clinical Investigation,45(8),775-781.
Aldrich, M. S.(1989).Automobile accidents in patients with sleep disorders.Sleep,12(6),487-494.
Anastasilakis, A. D.,Polyzos, S. A.,Saridakis, Z. G.,Kynigopoulos, G.,Skouvaklidou, E. C.,Molyvas, D.,Mantzoros, C. S.(2014).Circulating irisin in healthy, young individuals: Day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition.Journal of Clinical Endocrinology and Metabolism,99(9),3247-3255.

Times Cited ( 1 ) 〈TOP〉

陳聰毅、王冠捷(2017)。運動誘發鳶尾素對肥胖合併間歇性低氧引起心肌纖維化的影響。大專體育學刊，19(3)，272-287。

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