The Biological Characterization Evaluation of Gd(acac)TPP-Cremophor Micelles as an MRI Contrast Agent

磁振造影劑Gd(acac)TPP-Cremophor Micelles生物特性的評估

王愛義(Ai-Yih Wang) ； 張建文(Chien-Wen Jang) ； 羅俊光(Jiunn-Guang Lo)

《醫護科技學刊》 4卷3期 (2002/07) Pp. 193-202

https://doi.org/10.6563/TJHS.2002.4(3).1

摘要

本篇文章主要探討Gd(acac)TPP-Cremophor Micelles為MRT造影劑的可行性。實驗中，使用罹患肝癌的大白鼠和皮下腫瘤的小白鼠二種動物模式，利用42.5MHz的光譜儀和放射性核種153Gd物分布的特性。結果顯示Gd(acac)TPP-Cremophor Micelles的靶的器官為肝臟與脾臟，它主要由肝臟與腎臟代謝；在藥物注入24小時後，正常肝臟與肝腫瘤的滯留比為2.1；而皮下瘤與肌肉的藥物滯留比值為2.5。無論從具有肝腫瘤的大白鼠或是具有皮下腫瘤小白鼠的磁振造影影像顯示，二者皆能得到腫瘤與周圍正常組織清晰的對比影像。

關鍵字

釓 ； 克林莫佛膠粒 ； 磁振造影 ； 生物分布

並列摘要

The Gd(acac)TPP-cremophor micelles were prepared as a potential MRI contrast
agent in this research. Two experimental animal models were studied: one was using
hepatoma-bearing rats and the other, subcutaneous sarcoma-bearing mice were employed.
Both models were tested with a 42.5 MHz spectrometer and biodistribution study of
radioisotope153Gd. The results showed that target organs of the Gd(acac)TPP-cremophor micelles studies were liver and spleen respectively, and its metabolic pathway were mainly by liver and kidney. The retention ratio of the Gd(acac)TPP-crephomor micelles in normal liver to that of in hepatoma was to be 2.1, and in subcutaneous sarcoma to that in muscle was 2.5, after twenty-four hours administration, respectively. MR studies of the two models gave a satisfactory image contrast to the tumors.

並列關鍵字

gadolinium ； cremophor micelles ； MRI ； biodistribution

參考文獻

Wang, A. Y.,Jang C. W.,Lo J. G.(2002).Preparation of Gd(acac)TPP-Cremophor Micelles as an MRI Agent.The Journal of Health Science.4(2),136-145.

Carr, D. H.,Graif, M.,Niendrof, H. P.,Brown, J.,Steiner, R. E.,Blumgart, L. H.,Young I. R.(1986).Gadolinium-DTPA in the assessment of liver tumors by magnetic resonance imaging.Clinical Radiology.37,347-353.

Ceruti, M.,Crosasso, P.,Brusa, P.,Arpicco, S.,Dosio, F.,Cattel, L. J.(2000).Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing watersoluble prodrugs of paclitaxel.Journal of Controlled Release.63,141-153.

Engblom, P.,Pulkkinen, J. O.,Rantanen, V.,Hirvonen, H.,Kulmala, J.,Grenman, R.,Grenman, S.(1999).Effects of paclitaxel with or without cremophor EL on cellular clonogenic survival and apotosis.European Journal of Cancer.35(2),284-288.

Kabalka G. W.,Buonocore E.,Hunbner K.,Moss T.,Norley N.,Huang L.(1987).Gadolinium- labeled liposomes: targeted MR contrast agents for the liver and spleen.Radiology.163(1),255-258.