In 1960's neurologist Pribram viewed the brain as a three-dimensional hologram. He used this idea to explain the non-locality of brain functions. A number of extrasensory perception (ESP) studies have showed that the mind instead of the brain really perceives and manipulates things. Associated with these two aspects, the author tried to give a possible mechanism of conditioned response that was discovered by Pavlov in the late 19(superscript th) century. The mechanism is thought to be similar to the principle of holography developed by Gabor in 1940s.