After implementation of the National Healthcare Insurance policy in Taiwan, hospitals have to consider minimizing operating costs and to maintain the same level of medical quality in conducting daily operations. Previous MIS studies indicated that information technology (IT) is able to improve organizations' operating efficacy with the minimum costs. Although the healthcare industry is an IT intensive business, very few MIS related studies have been conducted in this particular area. There are many MIS related studies to be conducted in various types of industry, the results of these studies are not necessary true for the healthcare industry due to the unique characteristics of the healthcare industry. Thus, more studies in MIS perspectives are needed in the healthcare industry. The purpose of this paper is to propose the potential research issues in healthcare information systems.