Gemcitabine/Carboplatin Chemotherapy for Pure Small Cell Carcinoma of the Prostate: A Case Report

Gemcitabine及Carboplatin的複合性化學治療治療單純前列腺小細胞癌

陳冠州(Kuan-Chou Chen) ； 邱文祥(Allen W. Chiu) ； 江漢聲(Han-Sun Chiang) ； 朱娟秀(Jan-Show Chu) ； 鄭建睿(Chien-Jui Cheng)

《輔仁醫學期刊》 3卷1期 (2005/06) Pp. 17-23

摘要

前列腺小細胞癌為少見的前列腺惡性疾患。我們報告一位病人為單一細胞型態的單純小細胞癌，診斷時已合併骨骼及多重器官之轉移。病灶病理切片組織免疫特殊染色呈現chromogranin A, synaptophysin, and cytokeratins陽性，及陰性的PSA染色。病人在經尿道前列腺切除手術做出診斷後給予gemcitabine及carboplatin的複合性化學治療，其骨骼轉移病灶得到部分改善。

關鍵字

攝護腺 ； 小細胞癌 ； 神經內分泌 ； 組織免疫染色

並列摘要

Small cell carcinoma of the prostate is rare and is thought to behave clinically as a highly aggressive neoplasm. We report on a patient with pure small cell carcinoma of the prostate presenting as multiple organ metastases. Immunohistochemical studies of the tumor cells revealed positive reactions to chromogranin A, synaptophysin, and cytokeratin stains, and a negative reaction to PSA stain. This patient received 5 courses of gemcitabine/carboplatin chemotherapy after transurethral resection of the prostate, and the previous metastatic bone lesions showed partial resolution.

並列關鍵字

chemotherapy ； prostate ； small cell carcinoma ； neuroendocrine ； immunohistochemical studies