以定量式超音波評估血液透析病患之骨質密度

Evaluation of Bone Mineral Density in Hemodialysis Patients by Using Quantitative Ultrasound

鄭伊岑(Yi-Chen Cheng) ； 何上芸(Shang-Yun Ho) ； 張東浩(Tung-Hao Chang) ； 朱鐵吉(Tieh-Chi Chu) ； 郭瓊文(Chiung-Wen Kuo)

《台灣應用輻射與同位素雜誌》 5卷1期 (2009/03) Pp. 595-602

https://doi.org/10.29832/TJARI.200903.0004

摘要

The aim of the study was evaluated the relationship between bone quality and bone turnover rate in hemodialysis with diabetic patients by using quantitative ultrasound. To prevent mortality rate of fracture whether easily cause osteoporosis. One hundred and thirty-four subjects were enrolled in this study. Among them were 34 patients with hemodialysis with diabetic (age 26-80 years, mean age of 63.4±11.2 years, duration of dialysis 42.5 month) and 100 normal controls (age 48-82 years, mean age of 62.9±6.6 years). The bone quality of right calcaneal was measured by using quantitative ultrasound (QUS). Anthropometric data and reproductive history were collected from with questionnaire. No significant differences were found between hemodialysis and normal controls at QUI、 BUA、 SOS. In hemodialysis patients, all QUS parameters (SOS, BUA, QUI) were positively association with weight and BM1 (p＜0.01, p ＜0.05, respectively). In contrast, the negatively association the were between Alk-P and BUA (p＜0.05). Although there were negative relationship between biochemical parameter (Ca, i-PTH, Cr) and all QUS parameters, the statistically significant did not achieve (p＞0.05). The study suggested hemodialysis patients with diabetic compared could not been serious bone loss, when compared with controls subjects. We considered if increase dialysis period the occasion of bone loss was needed notice. Therefore, regular monitored bone quality to prevent the fracture rate became more important in long term hemodialysis patients.

關鍵字

定量式超音波 ； 血液透析 ； 糖尿病 ； 骨質轉換率

並列摘要

The aim of the study was evaluated the relationship between bone quality and bone turnover rate in hemodialysis with diabetic patients by using quantitative ultrasound. To prevent mortality rate of fracture whether easily cause osteoporosis. One hundred and thirty-four subjects were enrolled in this study. Among them were 34 patients with hemodialysis with diabetic (age 26-80 years, mean age of 63.4±11.2 years, duration of dialysis 42.5 month) and 100 normal controls (age 48-82 years, mean age of 62.9±6.6 years). The bone quality of right calcaneal was measured by using quantitative ultrasound (QUS). Anthropometric data and reproductive history were collected from with questionnaire. No significant differences were found between hemodialysis and normal controls at QUI、 BUA、 SOS. In hemodialysis patients, all QUS parameters (SOS, BUA, QUI) were positively association with weight and BM1 (p＜0.01, p ＜0.05, respectively). In contrast, the negatively association the were between Alk-P and BUA (p＜0.05). Although there were negative relationship between biochemical parameter (Ca, i-PTH, Cr) and all QUS parameters, the statistically significant did not achieve (p＞0.05). The study suggested hemodialysis patients with diabetic compared could not been serious bone loss, when compared with controls subjects. We considered if increase dialysis period the occasion of bone loss was needed notice. Therefore, regular monitored bone quality to prevent the fracture rate became more important in long term hemodialysis patients.

並列關鍵字

quantitative ultrasound ； hemodialysis ； diabetes mellitus ； bone turnover rate