Protective Mechanism against Gut Barrier Dysfunction in Mesenteric Ischemia/Reperfusion

Linda Chia-Hui Yu

《Adaptive Medicine》 2卷1期 (2010/04) Pp. 11-22

https://doi.org/10.4247/AM.2010.AAM007

並列摘要

Intestinal ischemia/reperfusion (I/R) results in mucosal barrier impairment and enhanced bacterial translocation (BT) into systemic circulation and extraintestinal visceral organs. Such bacterial influx may lead to the development of sepsis, systemic inflammatory response syndrome, and multiple organ failure. During ischemia, a lack of oxygen and glucose causes mitochondrial respiratory dysfunction, metabolic exhaustion, and an increase in intestinal epithelial cell death. The resultant mucosal histopathology is associated with impairment of barrier function and BT. Upon restoration of blood flow, production of free radicals from intestinal epithelial cells and mucosal phagocytes contribute to bactericidal activity; however, their prolonged activation inadvertently aggravates morphological and functional damage to the gut. Presently, several protective strategies have been developed to correct intestinal I/R injury. These include the use of antioxidants, nitric oxide, and antileukocyte methods, as well as preventive measures, such as ischemic preconditioning and enteric supplementation with particular nutrients.

並列關鍵字

gut barrier dysfunction ； mesenteric ischemia/reperfusion