Stem cell therapy for osteonecrosis

Osteonecrosis is a common disorder of bone, which if left untreated, will lead to progressive collapse of bone, and degeneration of the overlying articular cartilage. Recently, new techniques have been developed in which the osteonecrotic lesion is drilled (core decompression) and/or more extensively debrided, and osteoprogenitor cells from the iliac crest are harvested, concentrated and delivered to the lesion to enhance bone healing. In the earlier stages of osteonecrosis of the hip and knee without collapse or arthritic changes in the involved joint, the intermediate term results for preserving (rather than replacing) the joint using these techniques have been very encouraging. Future basic and clinical research is necessary to develop evidence-based algorithms to optimize patient selection, cell harvesting, expansion and delivery, preparation of the osteonecrotic lesion, biomechanical support and appropriate rehabilitation protocols.

並列關鍵字

avascular necrosis ； hip ； knee ； osteonecrosis ； osteoprogenitor cells ； stem cell therapy

被引用紀錄

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吳佳真（2009）。熱帶念珠菌失去異質合子性導致5-Flucytosine抗藥性及鑑別CaNDT80活化區重要胺基酸之研究〔碩士論文，國立交通大學〕。華藝線上圖書館。https://doi.org/10.6842/NCTU.2009.00839

林毓瑩（2011）。Slit2的exon15剪接變異型對抑制肺癌細胞生長及侵犯能力的影響〔博士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2011.00070

王瑜（2009）。探討機能性深層海洋飲用水於高油脂/ 膽固醇飲食下的保健功能-心血管與肝臟〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2009.00103

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延伸閱讀

洪晧彰、莊明哲、歐弘毅、蕭淑華、吳達仁（2007）。Recent Advance in Anti-Osteoporotic Therapy。內科學誌，18(6)，313-321。https://doi.org/10.6314/JIMT.2007.18(6).02
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Hernigou, P., Lachaniette, C. H. F., Bouthors, C., Roubineau, F., Chevallier, N., & Rouard, H. (2015). Osteonecrosis repair with stem cells: 30 years of experience from bone marrow concentration to cultured mesenchymal stem cells. Formosan Journal of Musculoskeletal Disorders, (), c1-11. https://doi.org/10.6492/FJMD.20160126

國際替代計量

Stem cell therapy for osteonecrosis

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