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簡介電化學在有機合成上的發展和應用

A Brief Overview of Organic Electrosynthesis

摘要


隨著對環境的重視,我們開始尋求環境友善的反應條件,而利用電驅動化學反應,取代傳統有機試劑為有機合成提供新的方向。本文介紹電化學在有機合成的基本概念和應用,從電解方式、電解槽配置到反應設計,並舉出近期藉由結合電化學方式,改善傳統上有機金屬耦聯反應的瓶頸,希望藉此幫助有興趣的讀者踏入電化學有機合成的領域。

並列摘要


Organic synthesis plays a vital role in modern chemistry, which enables one to construct molecules with specific physical and chemical properties for applications in medicinal chemistry, chemical biology and material science. Recently, the development of environmentally friendly and sustainable conditions applied for organic synthesis is highly desired. Particularly, organic electrosynthesis gains a great amount of attention as alternative strategy. Here, we start with the fundamental setup for electrolysis used for organic synthesis, the application of direct/mediated/ cation-pool electrolysis to the variants of paired electrolysis. Finally, the combination of electrosynthesis and conventional metal catalyzed cross-coupling reaction to overcome the challenging cross-coupling reactions will be presented. The aim of this article is to serve as a practical beginner's guide for an interesting reader to enter this exciting field.

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