A 72-year-old woman with an ant bite on her hand presented with anaphylaxis at the scene and chest pain in the emergency department. Electrocardiography showed a myocardial infarction with inferior and lateral wall ST elevation. She received percutaneous coronary intervention. The results revealed left anterior descending branch and right coronary artery obstruction. After stenting, she was discharged in good condition. Kounis syndrome was diagnosed. Emergency physicians should be alert to acute coronary syndrome following anaphylaxis.