適當使用人參不會減弱抗凝血劑Warfarin的效果

Adequately Taking Ginseng does not Reduce the Efficacy of Anticoagulation of Warfarin

陳安履(An-Lu Chen) ； 林舜穀(Shun-Ku Lin)

《台北市中醫醫學雜誌》 26卷2期 (2020/09) Pp. 17-22

https://doi.org/10.6718/TJCM.202009_26(2).0002

摘要

許多心血管疾病患者因為要長期控制凝血功能而在服用Warfarin，有動物實驗發現人參可能會降低Warfarin的抗凝血效果，因此許多醫師會建議病患避免服用。臨床研究顯示，心臟瓣膜置換病患與缺血性中風患者，若在醫師的監控下服用人參並不會降低Warfarin的抗凝血效果。但對於健康人而言，合併使用Warfarin和西洋參則可能會抑制抗凝血。

關鍵字

人參 ； Warfarin ； 抗凝血 ； 中西藥交互作用

並列摘要

Several patients with cardiovascular disease take Warfarin for a long time to regulate blood coagulation. Some animal studies revealed that taking Ginseng may inhibit the efficacy of anticoagulation of Warfarin. Consequently, many doctors very often advise their patients not to take it. However, clinical studies revealed that taking Ginseng does not inhibit anticoagulation of Warfarin for those patients who have valve replacement surgery or ischemic stroke under the supervision of their doctors. By contrast, taking Warfarin in combination with Xiyangshen may inhibit anticoagulation for healthy people.

並列關鍵字

Ginseng ； Warfarin ； Anticoagulation ； Herbal-drug Interactions

參考文獻

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Lee YH, Lee BK, Choi YJ, Yoon IK, Chang BC, Gwak HS. Interaction between warfarin and Korean red ginseng in patients with cardiac valve replacement.Int J Cardiol. 2010 Nov 19; 145(2): 275-6. doi: 10.1016/j.ijcard.2009.09.553.

Tuan CS, Wei G, Dey L, Karrison T, Nahlik L, Maleckar S, Kasza K, AngLee M, Moss J.Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled Trial. Ann Intern Med. 2004 Jul 6; 141(1): 23-7.

陳威傑、莊筱梅、陳昱瑋、許航甄、蔡嘉一：人參與 Warfarin 交互作用文獻回顧。中醫藥研究論叢；21 卷 1 期(2018/03/30)，51-56