To design a structure, it is often required to add or extract a substructure to meet the design criteria without re-analyzing the changed structure. This paper presents a generalized Modal Force Technique to deal with both coupling and decoupling problems for structural design. It directly works with the frequency response functions at joint points or break points to predict the dynamic behavior of a coupled structure or a decoupled structure. Using this method, there is fewer orders of the system matrix, no inversion of frequency response functions in system matrix, and the system matrix contains both information of the system and substructure modes. Numerical results indicate that the Modal Force Technique is effective for analyzing structural coupling and decoupling problems.